Organoborons

Research published in The Journal of Organic Chemistry, from Lippa, R. et al., has shown the access to substituted arylethylamines that are key structural components in natural, pharmaceutical, and agrochemical compounds. Substituted phenylethylamine and structurally related analogues represent a key pharmacophore found in endogenous and synthetic neurotransmitters, pharmaceutical agents, and agrochemical products including products such […]

Recent work from the MacMillan group at Princeton University was published in Science Journal presenting a biomimetic SH2 cross-coupling mechanism for quaternary sp3-carbon formation. This study examined the cross-coupling between tertiary redox-active esters and primary alkyl bromides in the presence of Fe(OEP)Cl as an effective SH2 catalyst, in tandem with Iridium based photocatalyst and the

Steven Bloom group present in ACS Catalysis a general catalytic platform to access diverse heteroaromatic radicals, aromatic and aliphatic radicals from commercial boronic acids using a cofactor-derived flavin photocatalyst in aqueous media. They showed the capability of these radicals to engage Michael acceptors via single-electron conjugate addition. In this method they demonstrated that water acts

Research from Ueda, M. et al., group at Osaka Prefecture University published in Organic Letters has shown that the α-boryl radical of potassium alkyltrifluoroborates have higher reactivity compared to their corresponding alkylboronic acid pinacol esters and alkyl N-methyl imidodiacetic acid (MIDA) boronates in the halogen atom abstraction step of atom-transfer radical addition (ATRA) between alkyl