Pyridinium porphyrins and AuNPs mediated bionetworks as SPR signal amplification tags for the ultrasensitive assay of brain natriuretic peptide

Work from the Chen group at Shanghai University published in Microchimica Acta described the development of a surface plasmon resonance (SPR) sensor using pyridinium porphyrin-mediated gold nanoparticle composites to amplify SPR signal when detecting B-type natriuretic peptide (BNP). The determination range for the sensor was shown to be broad and the experimental execution simple and easily performed. Thanks for […]

Pyridinium porphyrins and AuNPs mediated bionetworks as SPR signal amplification tags for the ultrasensitive assay of brain natriuretic peptide Read More »

Electrochemical properties and biomimetic activity of water-soluble meso-substituted Mn(III) porphyrin complexes in the electrocatalytic reduction of hydrogen peroxide

Recent work from the Mourzina group at Institute of Complex Systems-8 (Bioelectronics), Germany was published in Journal of Electroanalytical Chemistry presenting electrochemical properties and biomimetic activity of a series of water-soluble meso-substituted Mn(III) porphyrin complexes in the electrocatalytic reduction of hydrogen peroxide in aqueous solutions. The results of this study demonstrate that the electrochemical systems

Electrochemical properties and biomimetic activity of water-soluble meso-substituted Mn(III) porphyrin complexes in the electrocatalytic reduction of hydrogen peroxide Read More »

Pheophorbide-phenazinium conjugate as a fluorescent light-up probe for G-quadruplex structure

Olga A. Ryazanova, et. al. recently reported the synthesis and evaluation of a pheophorbide a phenazinium dye conjugate which is effective as a probe for G-quadruplex structures of nucleic acids. The fluorescence band of the aminophenazinium dye overlaps with the absorption band of pheophorbide a , resulting in the quenching of the phenazinium moiety by

Pheophorbide-phenazinium conjugate as a fluorescent light-up probe for G-quadruplex structure Read More »

Photostability of oxygen-sensitive core-shell nanofibers

Recent work from the Lannutti group at the Ohio State University was published in Journal of Sensors and Actuators B: Chemical, evaluating compositional parameters and other factors governing fiber design appropriate to long-term sensor applications. These nanofibers contain an oxygen-sensitive palladium (II) porphyrin species within a polysulfone core; an outer polycaprolactone shell protects the core from the surrounding environment. This study provides a detailed

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Pyridinium porphyrins and AuNPs mediated bionetworks as SPR signal amplification tags for the ultrasensitive assay of brain natriuretic peptide.

Recent work at Shanghai University by the Chen group was published in Microchimica Acta reporting a surface plasmon resonance biosensor for the determination of brain natriuretic peptide. Detection was accomplished by binding of the peptide to an amine functionalized aptamer probe. Pyridinium porphyrin-mediated Au nanoparticle composites were used to amplify the SPR signal. Thanks for

Pyridinium porphyrins and AuNPs mediated bionetworks as SPR signal amplification tags for the ultrasensitive assay of brain natriuretic peptide. Read More »

Topical photodynamic therapy of tumor bearing mice with meso-tetrakis (N-methyl-4-pyridyl) porphyrin loaded in ethosomes.

Recent work from the Farag group at the Cairo University, Giza, Egypt was published in Journal of Photodiagnosis and Photodynamic Therapy reassuring the usage of Meso-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP) as photosensitizing agent by loading in ethosomes. TMPyP (a photosensitizer) was considered for the topical treatment of subcutaneous tumors. The hydrophilicity of TMPyP hampers its skin penetration. TMPyP was formulated in nanovesicles called ethosomes to overcome the skin barrier and allow for its transdermal delivery.  Thanks for using our Meso-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP), T40125.  

Topical photodynamic therapy of tumor bearing mice with meso-tetrakis (N-methyl-4-pyridyl) porphyrin loaded in ethosomes. Read More »

Structure of a Zinc Porphyrin-Substituted Bacterioferritin and Photophysical Properties of Iron Reduction

Recent work from the Kurtz group at University of Texas was published in Biochemistry journal, presenting X-ray crystal structure of ZnPP-Bfr as well as the photophysical properties of the iron-loaded ZnPP-Bfr to better understand the process of photosensitized reductive iron release. The crystal structure of ZnPP-Bfr shows a unique six-coordinate zinc in the ZnPP with two axial methionine sulfur ligands.  Thanks for using our Protoporphyrin IX, (P562-9). 

Structure of a Zinc Porphyrin-Substituted Bacterioferritin and Photophysical Properties of Iron Reduction Read More »

Water-Soluble Nitroxyl Porphyrin Complexes FeIITPPSHNO and FeIITPPSNO− Obtained from Isolated FeIITPPSNO•

Recent work from the Doctorovich group at the University of Buenos Aires published in JACS identified the first biomimetic water-soluble FeII-porphyrin nitroxyl complexes. A pKa was calculated for the complex and reaction kinetics measured. DFT calculations implied the formation of a phlorin radical intermediate for the investigated reaction. Thanks for using our meso-tetra(4-sulfonatophenyl)porphine, T40699. 

Water-Soluble Nitroxyl Porphyrin Complexes FeIITPPSHNO and FeIITPPSNO− Obtained from Isolated FeIITPPSNO• Read More »

Dioxygen at Biomimetic Single Metal‑Atom Sites: Stabilization or Activation? The Case of CoTPyP/Au(111)

Recent work from the Vesselli group at the University of Trieste published in Topics in Catalysis demonstrated both experimental and computational results for the metal-organic framework (MOF) structure of 5,10,15,20-tetra(4-pyridyl)21H,23H-porphyrin cobalt(III) chloride assembled on a Au(111) surface. The generated MOF was able to mimic O2 stabilization and activation mechanisms typically observed in proteins and enzymes. Thanks for using our cobalt tetrapyridylporphyrin, T40892. 

Dioxygen at Biomimetic Single Metal‑Atom Sites: Stabilization or Activation? The Case of CoTPyP/Au(111) Read More »

Porphyrin loaded TyroSpheres for the intracellular delivery of drugs and photo-induced oxidant species.

Cat. No: D40922 Cat. No: T40637 TyroSphere nanoparticles consisting of the triblock polymer [poly(ethyleneglycol)-block-oligio(desaminotyrosine octyl ester suberate)-block -poly(ethyleneglycol)] aggregates were loaded with amphiphilic porphyrins as reported by Tsubone, et al. Meso-cis-di(N-methyl-4-pyridyl)diphenylporphine dichloride Cat. No: D40922 , which is a positively charged porphyrin and meso-cis-di(4-sulfonatophenyl)-diphenylporphine dihydrochloride Cat. No: T40637, a negatively charged porphyrin were used. The

Porphyrin loaded TyroSpheres for the intracellular delivery of drugs and photo-induced oxidant species. Read More »

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