The Influence of Effect of Polysaccharides and Polyvinylpyrrolidone on the Photocatalytic Activity of Chlorin e6 in Tryptophan Oxidation

A.B. Solov’eva et. al recently demonstrated in the Russian Journal of Physical Chemistry A that the addition of poly-N-vinylpyrrolidone (PVP) and the polysaccharides sodium alginate (SA) and hyaluronic acid (HA) to chlorin e6 (Ce6) increases the photosensitizing activity of Ce6 in the reaction of tryptophan oxidation.  While PVP, HA, and SA do not exhibit intrinsic photochemical activity, when employed as components of a conjugate with Ce6, they enhance the photochemical activity of Ce6 through disaggregation of the porphyrin photosensitizer associates present in the solution.  HA and SA increase the photochemical activity of Ce6 by 14%, while PVP raises it by 44%.  These findings are a useful contribution to the search for the most efficient pharmaceutical formulations of photosensitizers for use in antimicrobial photodynamic therapy.  Thanks for using our Chlorin e6 (Ce6).

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