Name: N-Methyl-3,6,9,12-tetraoxatridecan-1-amine
Molecular Formula: C10H23NO4
CAS#: 1059588-12-3
SMILES: COCCOCCOCCOCCNC
MDL#: MFCD26910507
Catalog#: AMTGC674-MA20
Molecular weight: 221.30 g/mol
Other names:
- mPEG4-NHMe
- N-Methyl-3,6,9,12-tetraoxatridecan-1-amine
- N-Methyl-PEG4-amine
- PEG4 methylamine
- Secondary amine PEG4 linker
Fields of Interest: bioconjugation, drug delivery, and materials science
Background
N-Methyl-3,6,9,12-tetraoxatridecan-1-amine is a monofunctional amine-functionalized PEG derivative based on a PEG4 backbone, featuring a terminal secondary amine. N-Methyl-PEG4-amine’s polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments while offering extended linker length for improved spatial separation and reduced steric hindrance. The secondary amine functionality offers tunable basicity and selective reactivity toward activated electrophiles such as NHS esters, activated carboxylic acids, and isocyanates. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for controlled and modular molecular modification.
Applications
N-Methyl-3,6,9,12-tetraoxatridecan-1-amine is commonly used in bioconjugation, drug delivery, and materials science applications where extended PEG spacing and controlled secondary amine reactivity are required. Typical uses include PEGylation of small molecules and polymers to improve solubility and stability, incorporation into ionizable or cationic systems, and preparation of intermediates for pharmaceutical and biomaterials research. The secondary amine enables selective functionalization while the PEG4 spacer provides flexibility and water compatibility. As part of a robust functionalized PEG product line, this compound supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless liquid
Purity: 97%
Storage: Room Temp
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Journal of Organic Chemistry, 2022, vol. 87, # 9, p. 5893 – 5903