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Synthesis of Arylethylamines via C(sp3)–C(sp3) Palladium-Catalyzed Cross-Coupling

Research published in The Journal of Organic Chemistry, from Lippa, R. et al., has shown the access to substituted arylethylamines that are key structural components in natural, pharmaceutical, and agrochemical compounds. Substituted phenylethylamine and structurally related analogues represent a key pharmacophore found in endogenous and synthetic neurotransmitters, pharmaceutical agents, and agrochemical products including products such […]

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High Reactivity of α-Boryl Radical of Potassium Alkyltrifluoroborate in Atom-Transfer Radical Addition

Research from Ueda, M. et al., group at Osaka Prefecture University published in Organic Letters has shown that the α-boryl radical of potassium alkyltrifluoroborates have higher reactivity compared to their corresponding alkylboronic acid pinacol esters and alkyl N-methyl imidodiacetic acid (MIDA) boronates in the halogen atom abstraction step of atom-transfer radical addition (ATRA) between alkyl

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