Zn(II) Mesoporphyrin IX CAS: 14354-67-7 MDL: MFCD09265024
Molecular weight: 630.083
Molecular Formula: C34H36N4O4Zn
CAS Number: 14354-67-7
Storage: Store at room temperature, protect from light.
Purity: >95%
Synonyms: 14354-67-7, 2,18-Bis(2-carboxyé
Fields of Interest: Heme Oxygenase, photocatalysis
Background: Zn(II) Mesoporphyrin IX is a natural porphyrin derivative specialty chemical manufactured by Frontier Specialty Chemicals. The bidistribution of Zn(II) Mesoporphyrin IX in rats and its relation to heme Oxygenase inhibition has been studied.1 Zn(II) Mesoporphyrin IX incorporated bacterioferritin on a nanoparticle scaffold was found to effective for the photosensitized generation of hydrogen.2 Zn(II) Mesoporphyrin IX was found to stimulate the human mitochondrial transporter ABCB10.3 Zinc Mesoporphyrin Induces Rapid Proteasomal Degradation of Hepatitis C Nonstructural 5A Protein in Human Hepatoma Cells.4 Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor bach1 and up-regulates HO-1.5 Zn(II) Mesoporphyrin IX was found to be toxic towards hemopoiesis.6
References:
1.) Russo, et al. Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase.
2.) Clark, et al. Photosensitized H2 generation from “one-pot” and “two-pot” assemblies of a zinc-porphyrin/platinum nanoparticle/protein scaffold. Dalton Trans., 2016,45, 630-638. https://doi.org/10.1039/C5DT03418C
3.) Martinez. et al. Stimulation of the human mitochondrial transporter ABCB10 by zinc-mesoporphrin. PLOS ONE Published: November 30, 202o https://doi.org/10.1371/journal.pone.0238754
4.) Hou, et al. Zinc Mesoporphyrin Induces Rapid Proteasomal Degradation of Hepatitis C Nonstructural 5A Protein in Human Hepatoma Cells. Gastroenterology. Volume 138, Issue 5, May 2010, Pages 1909-1919.e3.
5.) Hou, et al. Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor bach1 and up-regulates HO-1. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms. Volume 1779, Issue 3, March 2008, Pages 195-203. https://doi.org/10.1016/j.bbagrm.2008.01.006
6.) Lutton, et al. Comparative Pharmacology of Zinc Mesoporphyrin and Tin Mesoporphyrin: Toxic Actions of Zinc Mesoporphyrin on Hematopoiesis and Progenitor Cell Mobilization. Pharmacology.1999, Vol.58, January 1999. https://doi.org/10.1159/000028267
