Name: 2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(N-methylethanamine)
Molecular Formula: C10H24N2O3
CAS#: 68960-89-4
SMILES: CNCCOCCOCCOCCNC
MDL#: MFCD00628165
Catalog#: AMTGC803-OM21
Molecular weight: 220.31 g/mol
Other names:
- MeNH-PEG4-NHMe
- N,N’-Dimethyl-triethylene glycol diamine
- PEG3 secondary diamine
- Dimethylamino-PEG3-diamine
Fields of Interest: crosslinking, materials science, and drug delivery. PEG-based polymer networks, synthesis of ionizable or cationic intermediates, surface and nanoparticle modification
Background
2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(N-methylethanamine) is a symmetrical, bifunctional amine-functionalized PEG derivative based on a PEG3 backbone, featuring secondary amine groups at both termini. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and organic environments while offering moderate linker length for controlled molecular spacing. The terminal secondary amines provide tunable basicity and selective reactivity toward activated electrophiles such as NHS esters, activated carboxylic acids, and isocyanates. This diamine PEG derivative serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for modular molecular assembly and crosslinking applications.
Applications
2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(N-methylethanamine) is commonly used in crosslinking, materials science, and drug delivery applications where dual secondary amine functionality and PEG spacing are required. Typical uses include preparation of PEG-based polymer networks, synthesis of ionizable or cationic intermediates, surface and nanoparticle modification, and stepwise construction of multifunctional conjugates. The presence of two secondary amines enables controlled bifunctional coupling while the PEG3 spacer enhances flexibility and solubility. As part of a robust functionalized PEG product line, this compound supports modular design strategies in specialty chemical synthesis, biomaterials development, and advanced materials research.
Appearance: Colorless liquid
Purity: 98%
Storage: Room Temp
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 798 – 804
- Zhurnal Organicheskoi Khimii, 1984, vol. 20, # 4, p. 878 – 885
- Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 798 – 804