Name: 5,5-difluoro-2,8-diiodo-1,3,7,9,10-pentamethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine
Molecular Formula: C14H15BF2I2N2
CAS#: 1031443-55-6
SMILES: [F-][B+3]1([F-])[N]2=C(C(I)=C(C2=C(C3=C(C(I)=C([N-]31)C)C)C)C)C
MDL#:
Catalog#: D36275
Molecular weight: 513.90 g/mol
Other names:
- 2,6-diiodo-1,3,5,7,8-pentamethyl-pyrromethene fluoroborate
- 2,6-Diiodo-BODIPY 493/503
- 4,4-difluoro-2,6-diiodo-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene
- 2,6-Diiodo-Pyrromethene 546
Fields of Interest: Biomedical Imaging and Bioimaging, Fluorescent Sensing and Diagnostics, Materials Science and Optoelectronics, Therapeutics, Biological Imaging and Staining, Biomedical Diagnostics, Photodynamic Therapy, Photothermal Therapy, Optoelectronic Devices (OLEDs and OPVs)
Background & Applications:
5,5-Difluoro-2,8-diiodo-1,3,7,9,10-pentamethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine, also known as 2,6-Diiodo-Pyrromethene 546, is a specialized BODIPY dye intermediate used in drug discovery, fluorescent probe development, bioimaging, and advanced materials research. Identified by CAS 1031443-55-6, this iodinated boron-dipyrromethene (BODIPY) compound is valued for its functional fluorescent core and its utility in the synthesis of tailored dyes, labeled molecules, and imaging tools for pharmaceutical, life science, and specialty chemical research.
In drug discovery and chemical biology, 2,6-Diiodo-Pyrromethene 546 is useful as a BODIPY-based fluorescent building block for the development of probes, labeled ligands, assay reagents, and bioactive conjugates. The diiodo substitution pattern provides convenient reactive sites for cross-coupling, derivatization, and scaffold diversification, allowing researchers to prepare customized fluorescent molecules for screening assays, target engagement studies, cellular imaging, and structure-activity investigations. This makes it especially valuable for medicinal chemistry and translational research teams seeking robust fluorescent intermediates for discovery workflows.
Beyond pharmaceutical research, this BODIPY intermediate is also well suited for fluorescence imaging, sensor development, diagnostics research, photophysical studies, and optoelectronic materials design. Its boron-centered dye framework supports the development of novel fluorescent compounds with tunable properties for use in both academic and industrial R&D environments.
As part of a broader portfolio of BODIPY dyes and boron-containing fluorophores, 2,6-Diiodo-Pyrromethene 546 offers researchers a versatile platform for work in drug discovery, imaging, probe design, and specialty chemical synthesis.
Appearance: Bright red/orange solid
Purity: 98%
Storage: -20 °C
Solubility: DCM, DMSO
Literature:
- Journal of the American Chemical Society, 2024, vol. 146, # 2, p. 1644 – 1656,
- Journal of Photochemistry and Photobiology A: Chemistry, 2023, vol. 434, art. no. 114213