Name: Pyrromethene 546
Molecular Formula: C14H17BF2N2
CAS#: 121207-31-6
SMILES: [B-]1(N2C(=CC(=C2C(=C3[N+]1=C(C=C3C)C)C)C)C)(F)F
MDL#: MFCD00467372
Catalog#: P36274
Molecular weight: 262.11 g/mol
Other names:
- 5,5-Difluoro-1,3,7,9,10-pentamethyl-5H-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-4-ium-5-uide
- BODIPY 493/503
- 4,4-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indecene
Fields of Interest: Biomedical Imaging and Bioimaging, Fluorescent Sensing and Diagnostics, Materials Science and Optoelectronics, Therapeutics, Biological Imaging and Staining, Biomedical Diagnostics, Photodynamic Therapy, Photothermal Therapy, Optoelectronic Devices (OLEDs and OPVs)
Background & Applications:
Pyrromethene 546 is a high-performance BODIPY dye used in drug discovery, bioimaging, assay development, and advanced fluorescence research. As a boron-containing fluorophore, Pyrromethene 546 (CAS 121207-31-6) is well suited for the development of fluorescent probes, labeled molecules, analytical methods, and other research tools used across pharmaceutical, life science, and specialty chemical applications.
In drug discovery and chemical biology, Pyrromethene 546 is useful as a BODIPY fluorescent scaffold for the preparation of probes, conjugates, and assay reagents used in screening, target engagement studies, cellular imaging, and fluorescence-based workflow development. BODIPY dyes are widely valued for helping researchers monitor molecular interactions, evaluate compound behavior, and support discovery programs that rely on sensitive optical readouts. This makes Pyrromethene 546 a strong choice for medicinal chemistry, translational research, and other life science workflows requiring reliable fluorescent labeling tools.
Beyond pharmaceutical research, this BODIPY dye is also well suited for bioimaging, diagnostics research, sensor development, analytical chemistry, and laser dye applications. Its optical performance makes it attractive for both academic and industrial R&D programs focused on fluorescence technologies, imaging systems, and customized labeled compounds.
As part of a broader portfolio of BODIPY dyes and boron-containing fluorophores, Pyrromethene 546 offers researchers a versatile platform for drug discovery, imaging, assay development, and specialty chemical research.
Appearance: Red Solid
Purity: 98%
Storage: -20 °C
Solubility: DCM, DMSO
Literature:
- Organic Letters, 2025, vol. 27, # 44, p. 12217 – 12222
- Journal of the American Chemical Society, 2024, vol. 146, # 2, p. 1644 – 1656