Name: 2-(2-Methylamino-ethoxy)ethanol
Molecular Formula: C5H13NO2
CAS#: 85475-01-0
SMILES: OCCOCCNC
MDL#: MFCD12783671
Catalog#: AMTGC584-ME20
Molecular weight: 119.16 g/mol
Other names:
- 2-(Methylamino)ethoxyethanol
- 2-[2-(Methylamino)ethoxy]ethan-1-ol
- Methylamino-PEG1-alcohol
- Hydroxy-PEG1-methylamine
Fields of Interest: bioconjugation, materials science, and drug delivery
Background
2-(2-Methylaminoethoxy)ethanol is a compact, heterobifunctional amine-functionalized PEG derivative based on a PEG1 backbone, featuring a secondary amine and a terminal primary alcohol. The ether-containing spacer provides hydrophilicity, flexibility, and compatibility with aqueous and organic environments while maintaining a short linker length for tight spatial control. The secondary amine offers tunable basicity and selective reactivity toward activated electrophiles, while the hydroxyl group enables additional derivatization through esterification, ether formation, or conversion to activated intermediates. This dual-functional molecule serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for modular and controlled molecular modification.
Applications
2-(2-Methylaminoethoxy)ethanol is commonly used in bioconjugation, materials science, and drug delivery applications where compact PEG spacing and orthogonal functionality are required. Typical uses include preparation of multifunctional linkers, PEGylation of small molecules and polymers, synthesis of ionizable or cationic intermediates, and surface or nanoparticle modification. The combination of a reactive hydroxyl group and a secondary amine supports flexible, stepwise synthetic strategies and controlled tuning of physicochemical properties. As part of a robust functionalized PEG product line, this PEG1 amino alcohol supports modular design strategies in pharmaceutical research, diagnostics, biomaterials development, and specialty chemical synthesis.
Appearance: Colorless liquid
Purity: 99%
Storage: Room Temp
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Journal of the American Chemical Society, 2004, vol. 126, # 23, p. 7368 – 7377
- Beilstein Journal of Organic Chemistry, 2025, vol. 21, p. 727 – 735