Name: 2-(2-Methoxyethoxy)-N-methylethan-1-amine
Molecular Formula: C6H15NO2
CAS#: 124192-94-5
SMILES: CNCCOCCOC
MDL#: MFCD16107087
Catalog#: AMTGC655-MM20
Molecular weight: 133.19 g/mol
Other names:
- [2-(2-METHOXYETHOXY)ETHYL](METHYL)AMINE
- N-Methyl-2-(2-methoxyethoxy)ethanamine
- Methoxy-PEG2-methylamine
- PEG2 secondary amine linker
Fields of Interest: bioconjugation, materials science, and drug delivery, pharmaceutical and biomaterials research
Background
2-(2-Methoxyethoxy)-N-methylethan-1-amine is a monofunctional amine-functionalized PEG derivative based on a PEG2 backbone, featuring a terminal secondary amine and a methoxy-capped end. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and organic environments, while the methoxy terminus remains non-reactive to enable controlled, single-point functionalization. The secondary amine offers tunable basicity and selective reactivity toward activated electrophiles, making the compound useful in applications where controlled amine chemistry and compact PEG spacing are desired. This molecule serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable and modular molecular modification.
Applications
2-(2-Methoxyethoxy)-N-methylethan-1-amine is commonly used in bioconjugation, materials science, and drug delivery applications where compact PEG spacing and controlled secondary amine reactivity are required. Typical uses include PEGylation of small molecules and polymers to improve solubility and stability, incorporation into ionizable or cationic systems, and preparation of intermediates for pharmaceutical and biomaterials research. The methoxy-capped PEG chain ensures monofunctional behavior, while the secondary amine supports selective coupling and downstream functionalization. As part of a robust functionalized PEG product line, this compound supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless liquid
Purity: 99%
Storage: Room Temp
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Dalton Transactions, 2007, # 13, p. 1309 – 1315