Tetraacid

Tetraacid 6,6-bis(4-Carboxy-2-oxabutyl)-4,8-dioxaundecane-1,11-dicarboxylic acid CAS: 35638-19-8 MDL: MFCD08669605

Molecular weight: 424.4 g/mol 

Molecular Formula: C₁₇H₂₈O₁₂ 

CAS Number:  35638-19-8

Synonyms:  35638-19-8, TETRAACID, 3-[3-(2-carboxyethoxy)-2,2-bis(2-carboxyethoxymethyl)propoxy]propanoic acid, 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane, 3,3′-((2,2-Bis((2-carboxyethoxy)methyl)propane-1,3-diyl)bis(oxy))dipropanoic acid, 3,3′-[{2,2-Bis[(2-carboxyethoxy)methyl]propane-1,3-diyl}bis(oxy)]dipropanoic acid, NSC80081, SCHEMBL10215089

Storage:  Protect from moisture, at -20 °C. Protect from light. Corrosive.

Field of Interest: Dendrimer Synthesis, Newkome Dendrimers

Selected References: 

1. “Smart” Cascade Polymers. Modular Syntheses of Four-Directional Dendritic Macromolecules with Acidic, Neutral, or Basic Terminal Groups and the Effect of pH Changes on Their Hydrodynamic Radii, Young, James K.; Baker, Gregory R.; Newkome, George R.; Morris, Kevin F.; Johnson, Charles S., Jr., Macromolecules (1994), 27(13), 3464-71. DOI:10.1021/ma00091a004
2. Symmetrical, four-directional, poly(ether-amide) cascade polymers | Macromolecules (acs.org)s, Newkome, George R.; Lin, Xiaofeng, Macromolecules (1991), 24(6), 1443-4. DOI:10.1021/ma00006a042
3. Metallomicellanols: incorporation of ruthenium(II)-2,2′:6′,2”-terpyridine triads into cascade polymers, Newkome, George R.; Cardullo, Francesca; Constable, Edwin C.; Moorefield, Charles N.; Thompson, Alexander M. W. Cargill, Journal of the Chemical Society, Chemical Communications (1993), (11), 925-7. DOI:10.1039/C39930000925
4. Nanometric dendritic macromolecules: stepwise assembly by double(2,2′:6′,2″-terpyridine)ruthenium(I) connectivity – Journal of Materials Chemistry (RSC Publishing), Newkome, George R.; He, Enfei, Journal of Materials Chemistry (1997), 7(7), 1237-1244. DOI:10.1039/a700127d
5. Multiple Dendritic Catalysts for Asymmetric Transfer Hydrogenation | The Journal of Organic Chemistry (acs.org), Chen, Ying-Chun; Wu, Tong-Fei; Deng, Jin-Gen; Liu, Hui; Cui, Xin; Zhu, Jin; Jiang, Yao-Zhong; Choi, Michael C. K.; Chan, Albert S. C., Journal of Organic Chemistry (2002), 67(15), 5301-5306, DOI:10.1021/jo0257795
6. Poly(polyoxometalate) dendrimers: molecular prototypes of new catalytic materials, Zeng, Huadong; Newkome, George R.; Hill, Craig L., Angewandte Chemie, International Edition (2000), 39(10), 1772-1774. DOI:10.1002/(SICI)1521-3773(20000515)39:10<1771::AID-ANIE1771>3.0.CO;2-D
7. Chemistry of micelle series. 23. Polytryptophan terminated dendritic macromolecules, Newkome, George R.; Lin, Xiaofeng; Weis, Claus D., Tetrahedron:  Asymmetry (1991), 2(10), 957-60DOI:10.1016/S0957-4166(00)86135-2
8. Detection and Functionalization of Dendrimers Possessing Free Carboxylic Acid Moieties, Newkome, George R.; Weis, Claus D.; Moorefield, Charles N.; Weis, Ingrid, Macromolecules (1997), 30(8), 2300-2304. DOI:10.1021/MA961716A
9. Block and star block copolymers by mechanism transformation. VI. Synthesis and characterization of A4B4 miktoarm star copolymers consisting of polystyrene and polytetrahydrofuran prepared by cationic ring-opening polymerization and atom transfer radical polymerization, Yan-Ming; Pan, Cai-Yuan; Wang, Jian, Journal of Polymer Science, Part A: Polymer Chemistry (2001), 39(13), 2134-2142DOI:10.1002/pola.1189
10. Syntheses of New 1 → (2 + 1) C-Branched Monomers for the Construction of Multifunctional Dendrimers, Newkome, George R.; Kim, Hyung J.; Moorefield, Charles N.; Maddi, Hima; Yoo, Kyung-Soo, Macromolecules (2003), 36(12), 4345-4354DOI:10.1021/ma034319q,
11. Spirometallodendrimers: terpyridine-based intramacromolecular cyclization upon complexation – Chemical Communications (RSC Publishing)Newkome, George R.; Yoo, Kyung Soo; Moorefield, Charles N.Chemical Communications (Cambridge, United Kingdom) (2002), (18), 2164-2165. DOI:10.1039/b204512e
12. 6,6-Bis(carboxy-2-oxabutyl)-4,8-dioxaundecane-1,11-dicarboxylic acid, Newkome, George R.; Weis, Claus D., Organic Preparations and Procedures International (1996), 28(2), 242-4. DOI:10.1080/00304949609356531
13. Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs, Ouyang, Liang; Ma, Lifang; Jiang, Bo; Li, Yanhua; He, Dongsheng; Guo, Li, European Journal of Medicinal Chemistry (2010), 45(6), 2705-2711 DOI:10.1016/j.ejmech.2010.01.069
14. Segregated liquid crystalline dendritic supermolecules – multipedes based on pentaerythritol scaffolds, Saez, Isabel M.; Goodby, John W., Journal of Materials Chemistry (2003), 13(11), 2727-2739. DOI:10.1039/B303654E
15. New polypodal polycarboxylic ligands – complexation of rare-earth ions in aqueous solution, Romain; Serratrice, Guy; Dupraz, Agnes; Dupuy, Claude, European Journal of Inorganic Chemistry (2001), (7), 1789-1795. DOI:10.1002/1099-0682(200107)2001:7<1789::AID-EJIC1789>3.0.CO;2-C

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