Name: tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate (98%)
Molecular Formula: C15H32N2O5
CAS#: 194920-62-2
SMILES: O=C(OC(C)(C)C)NCCCOCCOCCOCCCN
MDL#: MFCD04973133
Catalog#: AMTGC275-BC17
Molecular weight: 320.42 g/mol
Other names:
- N-Boc-C1-PEG3-C3-NH2
- tert-Butyl N-[3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl]carbamate
- Boc-protected amino-PEG propyl linker
- Boc-PEG propylamine
Fields of Interest: PEGylation, bioconjugation, drug delivery, materials science
Background & Applications:
tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate is a protected amine-functionalized PEG derivative featuring a short PEG spacer and a terminal Boc-protected primary amine. The polyethylene glycol segment provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while the tert-butoxycarbonyl (Boc) protecting group enables controlled, stepwise synthetic strategies by temporarily masking amine reactivity. The Boc group can be readily removed under mild acidic conditions to generate the free primary amine for downstream conjugation. This compound serves as a versatile intermediate within a robust portfolio of functionalized PEGs designed for precise molecular assembly.
Applications
This Boc-protected PEG amine is commonly used in bioconjugation, drug delivery, and materials science applications where staged functional group exposure and controlled linker construction are required. Typical uses include stepwise synthesis of multifunctional PEG linkers, selective PEGylation of small molecules, peptides, or polymers, and preparation of intermediates for pharmaceutical and biomaterials research. Following deprotection, the resulting PEG amine is suitable for direct coupling to activated carboxylic acids, NHS esters, and isocyanates. As part of a comprehensive functionalized PEG product line, tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate supports modular design strategies for advanced chemical and biological applications.
Appearance: Colorless liquid
Purity: 98%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH
Literature:
- Journal of the American Chemical Society, 2000, vol. 122, # 11, p. 2663 – 2664
- WO2003/40093, 2003, A2
