Product Number: P226; CAS Number: 487-90-1

P226 Porphobilinogen Technical Data Sheet




SKU: P226 Category: Tag:

CAS: 487-90-1 MDL: MFCD00005224


Sizes Available:  5 mg, 10 mg, 100 mg, and larger sizes available

Molecular weight: 226.229 g/mol

Molecular Formula: C10H14N2O4                             

CAS Number: 487-90-1

Storage: Store at –20 °C, under Argon

Synonyms: CHEBI:17381, CHEMBL1235151, Porphobilinogen 5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid

Field of Interest: Natural Products Synthesis, Heme Containing Proteins, Hemoglobin, Myoglobin, Cytochrome C pathology, Complexes, Chlorophyll Biosynthesis

Background: Porphobilinogen is a pyrrole based natural product that is a starting material for the biosynthesis of porphyrins such as heme and chlorophyll. 1,2   It also is a main indicator of altered metabolism where porphobilinogen is indicative of lead poisoning and a biomarker and indicator of porphyria disease. 3,4


1.) Winslow S. Caughey, James A. Ibers, Crystal and Molecular Structure of the Free Base Porphyrin, Protoporphyrin IX Dimethyl Ester, J. Am. Chem. Soc99: 1977, 6639–6645.

2.) R. Battersby; C. J. R. Fookes; G. W. J. Matcham; E. McDonald, Biosynthesis of the pigments of life: formation of the macrocycle, Nature285: 1980, 17–21.

3.) Jaffe, Eileen K.; Martins, Jacob; Li, Jian; Kervinen, Jukka; Dunbrack, Roland L., Jr., The molecular mechanism of lead inhibition of human porphobilinogen synthase, Journal of Biological Chemistry (2001), 276(2), 1531-1537.  .

4.) Kauppinen, R.; Mustajoki, S.; Pihlaja, H.; Peltonen, L.; Mustajoki, P., Acute intermittent porphyria in Finland: 19 mutations in the porphobilinogen deaminase gene, Human Molecular Genetics (1995), 4(2), 215-22..



Functional Groups

, , , ,

Porphyrin Family

Porphyrin Building Blocks

Purity %


Molecular Formula

C10H14N2O4 x H2O

Molecular Weight



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