Name: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-(dimethylamino)naphthalene-1-sulfonamide
Molecular Formula: C20H31N3O5S
CAS#: 914311-67-4
SMILES: NCCOCCOCCOCCNS(=O)(C1=CC=CC2=C1C=CC=C2N(C)C)=O
MDL#: none
Catalog#: AMTGC1582-AN26
Molecular weight: 424.54 g/mol
Other names:
- Dansyl-PEG4-amine
- PEG4 fluorescent amine linker
- Dansyl-functionalized PEG amine
- 5-(Dimethylamino)-N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)naphthalene-1-sulfonamide
Fields of Interest: bioconjugation, fluorescent labeling, and chemical probe development
Background & Applications:
Background
N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-(dimethylamino)naphthalene-1-sulfonamide is a multifunctional amine-functionalized PEG conjugate featuring a PEG4 spacer linked to a dansyl (dimethylaminonaphthalene sulfonamide) fluorophore. The polyethylene glycol segment provides hydrophilicity, flexibility, and improved solubility, while spatially separating the fluorescent moiety from the reactive terminal primary amine. The amine functionality enables efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles, supporting site-specific conjugation. The dansyl group is a well-known environment-sensitive fluorophore widely used in fluorescence labeling and sensing applications. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for modular conjugation and optical probe development.
Applications
This Dansyl-PEG4-amine derivative is commonly used in bioconjugation, fluorescent labeling, and chemical probe development applications where both conjugation capability and optical detection are required. Typical uses include preparation of fluorescently labeled biomolecules, polymers, and surfaces, synthesis of imaging probes and diagnostics, and incorporation into materials for sensing or mechanistic studies. The combination of a reactive primary amine, a hydrophilic PEG spacer, and a fluorescent dansyl reporter enables controlled assembly of multifunctional probes with improved solubility and reduced nonspecific interactions. As part of a robust functionalized PEG product line, this compound supports advanced strategies in diagnostics, biomaterials, imaging, and specialty chemical synthesis.
Appearance: Orange, viscous liquid
Purity: 99%
Storage: Room Temp
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Tetrahedron Letters, 2013, vol. 54, # 49, p. 6682 – 6686
- Organic and Biomolecular Chemistry, 2015, vol. 13, # 12, p. 3648 – 3653
- Journal of the American Chemical Society, 2011, vol. 133, # 32, p. 12382 – 12385