Cu(II) Protoporphyrin IX CAS: 14494-37-2 MDL: MFCD01076447
Molecular weight: 624.188 g/mol
Molecular Formula: C34H32CuN4O4
CAS Number: 14494-37-2
Storage: Store at room temperature, protect from light
Synonyms: [3,3′-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κ2N21,N23)dipropanoato(2-)]copper, [3,3′-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κ2N21,N23)dipropanoato(2-)]kupfer, [3,3′-(3,7,12,17-Tétraméthyl-8,13-divinyl-2,18-porphyrinediyl-κ2N21,N23)dipropanato(2-)]cuivre, Copper, [8,13-diethenyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN21,κN23], 14494-37-2, Cu(II) Protoporphyrin IX, MFCD01076447
Field of Interest: Natural Porphyrins, Heme Oxygenase Pathway
Background: Cu (II) Protoporphyrin IX does not inhibit heme oxygenase (the enzyme that catalyzes the conversion of heme to biliverdin in the heme degradation pathway) and is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair.
References
1.) Jozkowicz, A., H. Was, et al. (2007). “Heme oxygenase-1 in tumors: is it a false friend?” Antioxid Redox Signal 9(12): 2099-117.
2.) Abraham, N. G. and A. Kappas (2005). “Heme oxygenase and the cardiovascular-renal system.” Free Radic Biol Med 39(1): 1-25.
3.) Kim, D. H., A. P. Burgess, et al. (2008). “Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells.” J Pharmacol Exp Ther 325(3): 833-40.
SDS
