Cr(III) Mesoporphyrin IX chloride 8,13,-Bis(ethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid chromium(III) chloride CAS: 70948-71-9 MDL: MFCD03425956

SDS

Molecular weight: 652.123 g/mol

Molecular Formula: C₃₄H₃₆ClCrN₄O₄

CAS Number: 70948-71-9

Storage: Store at room temperature, protect from light

Synonyms: Chloro[3,3′-(7,12-diethyl-3,8,13,17-tetramethyl-2,18-porphyrindiyl-κ²N²¹,N²³)dipropanoato(2-)]chromium, Chlor[3,3′-(7,12-diethyl-3,8,13,17-tetramethyl-2,18-porphyrindiyl-κ²N²¹,N²³)dipropanoato(2-)]chrom, Chloro[3,3′-(7,12-diethyl-3,8,13,17-tetramethyl-2,18-porphyrindiyl-κ²N²¹,N²³)dipropanoato(2-)]chromium, Chloro[3,3′-(7,12-diéthyl-3,8,13,17-tétraméthyl-2,18-porphyrinediyl-κ²N²¹,N²³)dipropanato(2-)], Chromium, chloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN²¹,κN²³]-, 70948-71-9, Cr(III) Mesoporphyrin IX chloride, MFCD03425956

Field of Interest: Heme Oxygenase, Heme Oxygenase Inhibitors

Background: Cr(III) Mesoporphyrin IX chloride is a natural porphyrin derivative specialty chemical manufactured by Frontier Specialty Chemicals. Cr(III) Mesoporphyrin IX chloride is a heme oxygenate inhibitor HO-1.^1-6

References:

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2.) Jin, et al. Beneficial effects of early (but not late) intervention of heme oxygenase-1 on bleomycin-induced pulmonary fibrosis in mice. Respiratory Physiology & Neurobiology. Volume 175, Issue 2, 15 February 2011, Pages 239-246. https://doi.org/10.1016/j.resp.2010.11.010

3.) Olszanecki, et al. The Role of Haem Oxygenase-1 in the Decrease of Endothelial Intercellular Adhesion Molecule-1 Expression by Curcumin. BCPT Volume 101, Issue 6, December 2007 Pages 411-415. https://doi.org/10.1111/j.1742-7843.2007.00151.x

4.) Ding, et al. Downregulation of Carbon Monoxide as well as Nitric Oxide Contributes to Peripheral Chemoreflex Hypersensitivity in Heart Failure Rabbits. FASEB Journal. Volume 20, Issue 5, Experimental Biology 2006 (Part II) March 2006 Pages LB35-LB35. https://doi.org/10.1096/fasebj.20.5.LB35-a

5.) Browe, et al. Gaseotransmitters Modulate Inspiratory Drive from the Hypoglossal Nucleus. FASEB Journal. Volume 36, Issue S1, May 2022. https://doi.org/10.1096/fasebj.2022.36.S1.R4975

6.) Olszanecki, R., Kurnyta, M., Biedroń, R. et al. The role of heme oxygenase-1 in down regulation of PGE₂ production by taurine chloramine and taurine bromamine in J774.2 macrophages. Amino Acids35, 359–364 (2008). https://doi.org/10.1007/s00726-007-0609-x