6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol

Name: 6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol 

Molecular Formula: C8H9BO3 

CAS#: 947162-87-0 

SMILES: OB1OCC2=CC=C(CO)C=C21 

MDL#: MFCD22572913 

Catalog#: H36220 

Molecular weight: 163.97 g/mol 

Other names: 

• 6-Hydroxymethylbenzoxaborole 

Fields of Interest: Building block in drug design, diagnostics and probes, drug discovery, medicinal chemistry, small molecule synthesis, scaffold development 

Background & Applications: 

6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol is a versatile benzoxaborole intermediate used in drug discovery, medicinal chemistry, and boron-containing small molecule synthesis. Identified by CAS 947162-87-0, this compound combines the distinctive reactivity of the benzoxaborole scaffold with a synthetically useful hydroxymethyl substituent, making it a valuable building block for the preparation of novel pharmaceutical candidates and advanced heterocyclic intermediates. 

In drug discovery, 6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol is especially useful as a medicinal chemistry building block for the synthesis of structurally diverse benzoxaborole derivatives. The benzoxaborole motif is of strong interest in pharmaceutical research because it can support unique interactions with biological targets, while the hydroxymethyl group provides a convenient handle for derivatization, linker installation, and broader scaffold diversification. This makes the compound well suited for lead generation, SAR studies, library synthesis, and lead optimization across a wide range of therapeutic research programs. 

Beyond pharmaceutical research, this benzoxaborole intermediate is also useful in chemical biology, boron-containing scaffold development, fragment-based research, and advanced organic synthesis. It can serve as a valuable precursor for the preparation of customized boron-based heterocycles and other specialty compounds used in both academic and industrial R&D settings. 

As part of a broader portfolio of benzoxaborole intermediates and boron-containing building blocks, 6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol offers researchers a flexible platform for drug discovery and specialty chemical applications. 

Appearance: White solid 

Purity: 98% 

Storage: 3-5°C 

Solubility: Ethyl acetate, Dichloromethane, chloroform, Diethyl ether 

Literature: Journal of Organic Chemistry, 2018, vol. 83, # 11, p. 6193 – 6201 

     Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3553 – 3557