5-Bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid

5-Bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid 5-Bromo-2-(trifluoromethyl)isonicotinic acid CAS: 749875-16-9 MDL: MFCD10687236

Molecular weight: 270.0 g/mol

Molecular Formula: C₇H₃BrF₄NO₂

CAS Number: 749875-16-9

Storage:  Store at 2-8 C^o, under dry conditions.

Synonyms:   5-bromo-2-(trifluoromethyl)isonicotinic acid, 5-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE-4-CARBOXYLIC ACID, 5-Bromo-2-trifluoromethyl-isonicotinic acid, MFCD10687236, 4-Pyridinecarboxylic acid, 5-bromo-2-(trifluoromethyl)-, SCHEMBL2990846

Uses:  Synthetic building block, fluorinated benzaldehyde, reactive bromine, reactive carboxylic acid, disubstituted intermediate

5-Bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid, is a synthetic specialty chemical used in the synthesis of pharmaceuticals and specialty organic chemicals.

Selected References and Patents:

1.) Preparation of imidazopyrimidines as EED inhibitors and the use thereof Wang, Shaomeng; Rej, Rohan; Wang, Changwei; Wang, Mi; Lu, Jianfeng; Yang, Chao-Yie; Fernandez-Salas, Ester; Stuckey, Jeanne PCT Int. Appl. (2021), WO 2021011713 A1 20210121,

2.) Preparation of (hetero)aromatic carboxamides as modulators of sodium channels for the treatment of diseases Ahmad, Nadia; Anderson, Corey; Arumugam, Vijayalaksmi; Asgian, Iuliana Luci; Camp, Joanne Louise; Fanning, Lev Tyler Dewey; Hadida Ruah, Sara Sabina; Hurley, Dennis; Schmidt, Yvonne; Shaw, David; et al From PCT Int. Appl. (2019), WO 2019014352 A1 20190117

3.) Preparation of pyrazolopyrimidine derivatives and their use as MALT1 inhibitors Pissot Soldermann, Carole; Quancard, Jean; Schlapbach, Achim; Simic, Oliver; Tintelnot-Blomley, Marina; Zoller, Thomas PCT Int. Appl. (2015), WO 2015181747 A1 20151203,

4.) Preparation of tetrahydropyrrolooxazolidinones as CETP inhibitors Shao, Pengcheng Patrick; Ye, Feng; Vachal, Petr; Sha, Deyou; Katipally, Revathi Reddy; Liu, Jian; Sun, Wanying PCT Int. Appl. (2013), WO 2013063217 A1 20130502,

5.) Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression Gillman, Kevin W.; Parker, Michael F.; Silva, Mark; Degnan, Andrew P.; Tora, George O.; Lodge, Nicholas J.; Li, Yu-Wen; Lelas, Snjezana; Taber, Matthew; Krause, Rudolf G.; et al From Bioorganic & Medicinal Chemistry Letters (2013), 23(2), 407-411. DOI:10.1016/j.bmcl.2012.11.094

6.) Preparation of benzenesulfonylamide derivatives as Gonadotropin-releasing hormone receptor antagonists Ashweek, Neil; Chen, Mi; Coon, Timothy Richard; Ewing, Todd; Jiang, Wanlong; Moree, Willy; Rowbottom, Martin; Wade, Warren; Zhao, Liren; Zhu, Yun-Fei; et alPCT Int. Appl. (2008), WO 2008124614 A1 20081016,

7.) Preparation of benzenecarboxamide derivatives as Gonadotropin-releasing hormone receptor antagonists Beaton, Graham; Chen, Mi; Coon, Timothy Richard; Ewing, Todd; Jiang, Wanlong; Lowe, Richard; Moree, Willy; Smith, Nicole; Wade, Warren; Zhao, Liren; et alPCT Int. Appl. (2008), WO 2008124610 A1 20081016,

8.) Further metalations and functionalizations of chloro-, bromo- and iodo(trifluoromethyl)pyridines Cottet, Fabrice; Marull, Marc; Mongin, Florence; Espinosa, David; Schlosser, Manfred From Synthesis (2004), (10), 1619-1624. DOI:10.1055/s-2004-829111

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