Name: 2,5,8,11,14-Pentaoxahexadecan-16-amine (99%)
Molecular Formula: C11H25NO5
CAS#: 5498-83-9
SMILES: COCCOCCOCCOCCOCCN
MDL#: MFCD27977523
Catalog#: AMTGC325-PA17
Molecular weight: 251.32 g/mol
Other names:
- mPEG5-Amine
- Methyl-PEG5-amine
- 2,5,8,11,14-Pentaoxahexadecan-16-amine
Fields of Interest: PEGylation, bioconjugation, drug delivery, materials science
Background & Applications:
Background
2,5,8,11,14-Pentaoxahexadecan-16-amine (CAS 5498-83-9) is a monofunctional amine-terminated PEG derivative based on a PEG5 backbone, featuring a terminal primary amine. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while offering extended linker length for spatial separation and conformational freedom. The primary amine functionality enables efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable molecular modification.
Applications
2,5,8,11,14-Pentaoxahexadecan-16-amine is commonly used in bioconjugation, drug delivery, and materials science applications where extended PEG spacing and monofunctional amine reactivity are required. Typical uses include PEGylation of small molecules, peptides, and polymers to enhance solubility and stability, surface and nanoparticle functionalization, and preparation of intermediates for pharmaceutical and biomaterials research. As part of a robust functionalized PEG product line, this PEG5 amine supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless liquid
Purity: 99%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH
Literature:
- Journal of Pharmaceutical and Biomedical Analysis, 2025, vol. 259, art. no. 116767
- Journal of the American Chemical Society, 1994, vol. 116, # 12, p. 5057 – 5062
