2-(Chloromethyl)-6-(trifluoromethyl)pyridine

2-(Chloromethyl)-6-(trifluoromethyl)pyridine CAS: 849094-03-7 MDL: MFCD13188826

Molecular weight:    195.57     g/mol

Molecular Formula: C₇H₅ClF₃N

CAS Number:  849094-03-7

Storage:               Store at 2-8 C^o, under dry conditions.

Synonyms:   2-(chloromethyl)-6-(trifluoromethyl)pyridine, 849094-03-7

2-chloromethyl-6-trifluoromethylpyridine, Pyridine, 2-(chloromethyl)-6-(trifluoromethyl)-, SCHEMBL2305694

Uses:     Synthesis building block, Organic Synthesis, pyridine nitrogen heterocycle,  synthesis, chlorine reactions

2-(Chloromethyl)-6-(trifluoromethyl)pyridine, is a synthetic fine chemical useful in the synthesis of pharmaceuticals and fine organic chemicals.

Selected Patents and Uses:

1. Altenbach, R. J.; Bogdan, A.; Desroy, N.; Gfesser, G. A.; Greszler, S. N.; Kym, P. R.; Liu, B.; Malagu, K. F.; Merayo Merayo, N.; Pizzonero, M. R.; Searle, X. B.; Van der Plas, S. E.; Wang, X.; Yeung, M. C.; Zhao, G. Preparation of sulfonyltetrahydronaphthalenecarboxamide derivatives and analogs for use as cystic fibrosis transmembrane conductance regulator protein modulators. WO2018154519A1, 2018.
2. Bacani, G. M.; Chai, W.; Edwards, J. P.; Smith, R. C.; Tichenor, M. S.; Venable, J. D.; Wei, J. Preparation of diaminopyrimidine derivatives for use as histamine H4 modulators. WO2018187652A1, 2018.
3. Balog, J. A.; Cherney, E. C.; Shan, W.; Williams, D. K.; Zhang, L. Carboxamides and ureas as inhibitors of indoleamine 2,3-dioxygenase and their preparation. WO2019074822A1, 2019.
4. Biber, N.; Brockschneider, D.; Gericke, K. M.; Koelling, F.; Lustig, K.; Meding, J.; Meier, H.; Neubauer, T.; Schaefer, M.; Timmermann, A.; Zubov, D.; Terjung, C.; Lindner, N.; Badock, V.; Moosmayer, D.; Miyatake Ondozabal, H.; Moore, S.; Schulz, A. Preparation of 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones useful for treatment and prophylaxis of inflammatory pulmonary diseases. WO2017194459A1, 2017.
5. Godbout, C.; Trieselmann, T.; Vintonyak, V. Preparation of oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors. WO2018024653A1, 2018.
6. Petrassi, H. M. J.; Peram Surakattula, M. M. R.; Maedler, K.; Ardestani, A.; Roland, J. T.; Baguley, T. D.; Tremblay, M. S.; Shen, W.; Schultz, P. G.; Chatterjee, A. K. Preparation of compounds for inhibiting mammalian sterile 20-like kinase 1. WO2016210345A1, 2016.
7. Polasek, M. Compounds for separation of rare earth elements and s-, p-, d- metals, method of separation, and use thereof. WO2019106182A1, 2019.
8. Polasek, M. Compounds for separation of rare earth elements and s-, p-, d- metals, method of separation, and use thereof. EP3492460A1, 2019.
9. Velaparthi, U.; Chupak, L. S.; Darne, C. P.; Ding, M.; Gentles, R. G.; Huang, Y.; Kamble, M. N. R.; Martin, S. W.; Mannoori, R.; McDonald, I. M.; Olson, R. E.; Rahaman, H.; Jalagam, P. R.; Roy, S.; Tonukunuru, G.; Velaiah, S.; Warrier, J. S.; Zheng, X.; Tokarski, J. S.; Dasgupta, B.; Reddy, K. R.; Raja, T. Preparation of substituted naphthyridinone compounds useful as T cell activators. WO2020006018A1, 2020.
10. Williams, D. K.; Shan, W.; Zhang, L.; Cherney, E. C.; Balog, J. A. Preparation of inhibitors of indoleamine 2,3-dioxygenase and their use as antitumor agents. WO2017192813A1, 2017.