Name: 2-(2-Ethoxyethoxy)ethanamine
Molecular Formula: C6H15NO2
CAS#: 23702-88-7
SMILES: NCCOCCOCC
MDL#: MFCD09805423
Catalog#: AMTGC290-AM17
Molecular weight: 133.19 g/mol
Other names:
- 2-(2-Ethoxyethoxy)ethylamine
- Ethoxy-PEG2-amine
- PEG2 amine ethyl ether
Fields of Interest: bioconjugation, drug delivery, and materials science
Background & Applications:
Background
2-(2-Ethoxyethoxy)ethanamine is a monofunctional amine-terminated PEG derivative based on a PEG2 backbone, featuring a terminal primary amine and an ethoxy-capped end. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while the ethoxy terminus remains non-reactive to enable controlled, single-point functionalization. The primary amine allows efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable and selective molecular modification.
Applications
2-(2-Ethoxyethoxy)ethanamine is commonly used in bioconjugation, drug delivery, and materials science applications where compact PEG spacing and monofunctional amine reactivity are required. Typical uses include PEGylation of small molecules, peptides, and polymers to enhance solubility and stability, surface and nanoparticle modification, and preparation of functional intermediates for pharmaceutical and biomaterials research. The ethoxy-capped PEG chain ensures controlled incorporation of a single reactive site. As part of a robust functionalized PEG product line, this compound supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless liquid
Purity: 97%
Storage: -20 °C
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Journal of the American Chemical Society, 2015, vol. 137, # 51, p. 16196 – 16202
- Tetrahedron, 1991, vol. 47, # 30, p. 5867 – 5876