Name: 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine
Molecular Formula: C7H17NO3
CAS#: 74654-07-2
SMILES: NCCOCCOCCOC
MDL#: MFCD17215909
Catalog#: AMTGC223-MA16
Molecular weight: 163.21 g/mol
Other names:
- 2-[2-(2-methoxyethoxy)ethoxy]ethylamine
Fields of Interest: PEGylation, bioconjugation, drug delivery, and materials science
Background & Applications:
Background
2-(2-(2-Methoxyethoxy)ethoxy)ethanamine (CAS 74654-07-2) is a monofunctional amine-terminated PEG derivative based on a PEG3 backbone, featuring a terminal primary amine and a methoxy-capped end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while the methoxy terminus remains non-reactive to allow controlled, single-point functionalization. The primary amine enables efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable molecular modification.
Applications
2-(2-(2-Methoxyethoxy)ethoxy)ethanamine is commonly used in bioconjugation, drug delivery, and materials science applications where monofunctional amine reactivity and defined PEG spacing are required. Typical uses include PEGylation of small molecules, peptides, and polymers to improve solubility and stability, surface and nanoparticle modification, and preparation of functional intermediates for pharmaceutical and biomaterials research. As part of a robust functionalized PEG product line, this amine-terminated, methoxy-capped PEG supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless liquid
Purity: 99%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH
Literature:
- Chemische Berichte, 1980, vol. 113, # 5, p. 1691 – 1707
- European Journal of Medicinal Chemistry, 1991, vol. 26, # 4, p. 461 – 467
