2-{2-[2-(2-Methoxy-ethylamino)-ethoxy]-ethoxy}-ethanol (98%)

Name: 2-{2-[2-(2-Methoxy-ethylamino)-ethoxy]-ethoxy}-ethanol 

Molecular Formula: C9H21NO4 

CAS#: 1818397-10-2 

SMILES: OCCOCCOCCNCCOC 

MDL#: MFCD32705035 

Catalog#: AMTGC558-ME20 

Molecular weight: 207.15 g/mol 

Other names: 

• N-(2-Methoxyethyl)-2-[2-(2-hydroxyethoxy)ethoxy]ethanamine  

• 2-[2-[2-(2-Methoxyethylamino)ethoxy]ethoxy]ethan-1-ol  

• Methoxyethylamino-PEG3-alcohol  

• Secondary amine PEG alcohol linker 

Fields of Interest: bioconjugation, drug delivery, materials science, and specialty chemical synthesis 

Background & Applications:  

Background 

Methoxyethylamino-PEG3-alcohol is a multifunctional amine-functionalized PEG derivative based on a PEG3 backbone, featuring a secondary methylamine, a terminal primary alcohol, and a methoxyethyl substituent. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and organic environments, while the combination of ether linkages and amino functionality offers a balance of solubility, reactivity, and molecular flexibility. The secondary amine can participate in alkylation, acylation, and conjugation reactions, while the terminal hydroxyl group serves as a versatile handle for esterification, etherification, or conversion to activated intermediates. This compound serves as a valuable building block within a comprehensive portfolio of functionalized PEGs designed for modular synthesis, linker development, and advanced materials applications. 

Applications 

Methoxyethylamino-PEG3-alcohol is commonly used in bioconjugation, drug delivery, materials science, and specialty chemical synthesis applications where hydrophilic spacing and controlled amine reactivity are required. Typical uses include preparation of PEGylated intermediates, synthesis of ionizable or cationic molecules, incorporation into surfactants and specialty polymers, and construction of multifunctional linkers through selective modification of the hydroxyl and amine groups. The combination of a secondary amine, a terminal alcohol, and a PEG3 spacer enables flexible, stepwise synthetic strategies and tuning of physicochemical properties. As part of a robust functionalized PEG product line, this compound supports modular design approaches in pharmaceutical research, diagnostics, biomaterials development, and advanced materials synthesis. 

Appearance: Light yellow liquid 

Purity: 98% 

Storage: Room Temperature 

Solubility: Dichloromethane, Chloroform, Methanol 

Literature: None found listing this compound specifically. This is fairly common for specialized PEG linker intermediates, which are often used as synthetic building blocks and therefore appear only as unnamed intermediates within patent literature or supplementary synthetic schemes rather than as focal compounds in journal articles. 

Here are some publications that discuss the broader amino-functionalized PEG linker class to which this compound belongs: 

• Knop, K.; Hoogenboom, R.; Fischer, D.; Schubert, U.S. Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives. Angewandte Chemie International Edition 2010, 49(36), 6288–6308. This widely cited review discusses the properties and applications of PEG-based linkers, including amino-functional PEG derivatives used in drug delivery, bioconjugation, and biomaterials.  

• Zalipsky, S. Chemistry of Polyethylene Glycol Conjugates with Biologically Active Molecules. Bioconjugate Chemistry 1995, 6(2), 150–165. This foundational review describes the synthesis and use of amino-functionalized PEG reagents and linker technologies that form the basis of modern PEGylation and conjugation strategies.