Name: 14-Azido-3,6,9,12-tetraoxatetradecan-1-amine (97%)
Molecular Formula: C10H22N4O4
CAS#: 951671-92-4
SMILES: NCCOCCOCCOCCOCCN=[N+]=[N-]
MDL#: MFCD20134134
Catalog#: AMTGC261-TA17
Molecular weight: 262.31 g/mol
Other names:
- N3-PEG3-CH2CH2NH2
- Azido-PEG4-amine
- α-Amino-ω-azido-tetraethylene glycol
Fields of Interest: PEGylation, click chemistry, bioconjugation, drug delivery, materials science
Background & Applications:
Background
14-Azido-3,6,9,12-tetraoxatetradecan-1-amine (CAS 951671-92-4) is a heterobifunctional azide-functionalized PEG linker based on a PEG4 backbone, featuring a terminal azide group and a primary amine at opposite ends of the molecule. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments while offering defined linker length for spatial control. The azide functionality enables efficient bioorthogonal click chemistry, including CuAAC and strain-promoted azide–alkyne cycloaddition, while the primary amine allows straightforward coupling to activated carboxylic acids, NHS esters, and isocyanates. This dual-functional PEG linker is a versatile building block within a comprehensive portfolio of functionalized PEGs designed for precise molecular assembly.
Applications
14-Azido-3,6,9,12-tetraoxatetradecan-1-amine is commonly used in bioconjugation, drug delivery, and materials science applications where orthogonal reactivity and extended PEG spacing are required. Typical uses include site-specific attachment of PEG chains to peptides, proteins, polymers, or surfaces via click chemistry followed by amide bond formation, preparation of multifunctional intermediates, and construction of PEG-based linkers for biomaterials and advanced materials research. As part of a robust functionalized PEG product line, this azido–amine PEG4 linker supports modular design strategies in pharmaceutical research, diagnostics, and specialty chemical synthesis.
Appearance: Pale yellow liquid
Purity: 97%
Storage: -20°C
Solubility: DCM, Chloroform, MeOH
Literature:
- Synthesis, 2021, vol. 53, # 22, p. 4263 – 4271
- Journal of Medicinal Chemistry, 2009, vol. 52, # 15, p. 4903 – 4910
