Name: 13-Azido-2,5,8,11-tetraoxatridecane
Molecular Formula: C9H19N3O4
CAS#: 606130-90-9
SMILES: COCCOCCOCCOCCN=[N+]=[N-]
MDL#: MFCD13184960
Catalog#: AMTGC288-TA17
Molecular weight: 233.26 g/mol
Other names:
- 1-Azido-2,5,8,11-tetraoxatridecane
- Azido-PEG4
- PEG4 monofunctional azide
Fields of Interest: bioconjugation, drug delivery, and materials science
Background & Applications:
Background
13-Azido-2,5,8,11-tetraoxatridecane is an Azido-PEG4 monofunctional azide-functionalized PEG derivative based on a PEG4 backbone, featuring a terminal azide group and a non-reactive alkyl terminus at the opposite end. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while offering defined linker length for improved spatial separation. The azide functionality enables efficient bioorthogonal click chemistry, including CuAAC and strain-promoted azide–alkyne cycloaddition, allowing selective and site-specific conjugation. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for controlled molecular modification.
Applications
13-Azido-2,5,8,11-tetraoxatridecane is commonly used in bioconjugation, drug delivery, and materials science applications where monofunctional azide reactivity and extended PEG spacing are required. Typical uses include click-based attachment of PEG chains to small molecules, polymers, or surfaces to enhance solubility and reduce non-specific interactions, as well as preparation of PEGylated intermediates for diagnostics and imaging. The presence of a single reactive azide ensures controlled, one-point functionalization. As part of a robust functionalized PEG product line, this PEG4 azide supports modular design strategies in pharmaceutical research, biomaterials development, and specialty chemical synthesis.
Appearance: Light-orange liquid
Purity: 97%
Storage: -20 °C
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Molecules, 2015, vol. 20, # 9, p. 16085 – 16102
- Journal of the American Chemical Society, 1994, vol. 116, # 12, p. 5057 – 5062