Name: 1,26-Diazido-3,6,9,12,15,18,21,24-octaoxahexacosane
Molecular Formula: C18H36N6O8
CAS#: 361543-07-9
SMILES: [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
MDL#: MFCD29079429
Catalog#: AMTGC1603-OH26
Molecular weight: 464.51 g/mol
Other names:
- PEG8 diazide
- Azido-PEG8-azide
- Diazido-PEG8
- N₃-PEG8-N₃
- α,ω-Diazido-octaethylene glycol
Fields of Interest: click chemistry, crosslinking, bioconjugation, drug delivery, and materials science
Background & Applications:
Background
PEG8 diazide is a symmetrical, bifunctional diazide-functionalized PEG derivative based on a PEG8 backbone, featuring azide groups at both termini. The extended polyethylene glycol spacer provides excellent hydrophilicity, flexibility, and compatibility with aqueous and biological environments while offering substantial linker length for increased spatial separation and reduced steric hindrance. The terminal azide functionalities enable highly efficient bioorthogonal click chemistry, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) and strain-promoted azide–alkyne cycloaddition, allowing simultaneous or stepwise conjugation at both ends of the molecule. This long-chain PEG linker serves as a versatile building block within a comprehensive portfolio of functionalized PEGs designed for modular molecular assembly, crosslinking, and advanced bioconjugation applications. Similar compounds in this family are commonly marketed as PEG diazides for click chemistry and linker development.
Applications
PEG8 diazide is commonly used in crosslinking, bioconjugation, drug delivery, and materials science applications where dual click reactivity and extended PEG spacing are required. Typical uses include construction of PEG-based polymer networks, preparation of multifunctional intermediates, surface and nanoparticle modification, and assembly of advanced biomaterials through click chemistry. The longer PEG8 spacer provides enhanced flexibility, improved aqueous solubility, and greater molecular reach compared with shorter PEG diazides, making it particularly useful when minimizing steric effects or bridging larger molecular structures. As part of a robust functionalized PEG product line, this PEG8 diazide supports modular design strategies in pharmaceutical research, diagnostics, biomaterials development, and specialty chemical synthesis. Diazide PEG linkers are widely employed as click-reactive crosslinkers and molecular spacers in advanced conjugation workflows.
Appearance: Pale yellow liquid
Purity: 99%
Storage: Room temperature
Solubility: Dichloromethane, Chloroform, Methanol
Literature:
- Tetrahedron Letters, 2001, vol. 42, # 23, p. 3819 – 3822
- Journal of Polymer Science, Part A: Polymer Chemistry, 2013, vol. 51, # 1, p. 190 – 202