Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol 8,13-Bis(1,2 dihydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine- 2,18-dipropionic acid zinc(II) ZnBG CAS: 119700-81-1 MDL: MFCD00672307
Molecular weight: 694.08Â g/mol
Molecular Formula:Â C34H36N4O8Zn
CAS Number:Â 119700-81-1
Storage: Store at room temperature, protect from light
Synonyms:Â Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol, 8,13-Bis(1,2 dihydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine- 2,18-dipropionic acid zinc(II), ZnBG, 119700-81-1, MFCD00672307
Field of Interest:Â Heme Oxygenase Inhibitors, Heme Oxygenase Pathway
Background: Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol or ZnBG is a potent heme-oxygenase inhibitor with a short duration of action.1-4
References:
1.) He, C. X., Campbell, C. M., Zhao, H., Kalish, F. S., Schulz, S., Vreman, H. J., Wong, R. J., and Stevenson, D. K. (2011). Effects of zinc deuteroporphyrin bis glycol on newborn mice after heme-loading. Pediatr. Res. 70, 467–472.
2.) Vreman, H. J., Lee, O. K., and Stevenson, D. K. (1991). In vitro and in vivo characteristics of a heme oxygenase inhibitor: ZnBG. Am. J. Med. Sci. 302, 335–341.
3.) Martasek, P., Solangi, K., Goodman, A. I., Levere, R. D., Chernick, R. J., and Abraham, N. G. (1988). Properties of human kidney heme oxygenase: inhibition by synthetic heme analogues and metalloporphyrins. Biochem. Biophys. Res. Commun. 157, 480–487
4.) Schulz, et al. Metalloporphyrins – an update. Front. Pharmacol., 26 April 2012 Volume 3 – 2012 | https://doi.org/10.3389/fphar.2012.00068
