Name: tert-Butyl (2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)(methyl)carbamate
Molecular Formula: C14H28N4O5
CAS#: 1260430-85-0
SMILES: CN(C(OC(C)(C)C)=O)CCOCCOCCOCCN=[N+]=[N-]
MDL#: MFCD32217483
Catalog#: AMTGC1242-BA24
Molecular weight: 232.28 g/mol
Other names:
- 1260430-85-0
Fields of Interest: PEGylation, bioconjugation, drug delivery, materials science, click chemistry
Background & Applications:
Background
tert-Butyl (2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)(methyl)carbamate (CAS 1260430-85-0) is a protected azide-functionalized PEG derivative based on a PEG4 backbone, featuring a terminal azide group and a Boc-protected secondary amine. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while the Boc protecting group enables controlled, stepwise synthetic strategies and temporary masking of the amine functionality. The azide group supports efficient bioorthogonal click chemistry, including CuAAC and strain-promoted azide–alkyne cycloaddition. This compound is a versatile intermediate within a robust portfolio of functionalized PEGs designed for precise molecular assembly.
Applications
This Boc-protected azido PEG carbamate is commonly used in bioconjugation, drug delivery, and materials science applications where orthogonal reactivity and staged functional group exposure are required. Typical uses include stepwise construction of multifunctional linkers, selective PEGylation of small molecules or polymers, and preparation of intermediates for pharmaceutical and biomaterials research. Following deprotection, the resulting azido–secondary amine PEG is suitable for direct coupling to activated carboxylic acids, NHS esters, and isocyanates. As part of a comprehensive functionalized PEG product line, tert-Butyl (2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)(methyl)carbamate supports modular design strategies for advanced chemical and biological applications.
Appearance: Pale yellow liquid
Purity: 99%
Storage: 0-3 °C for long term storage
Solubility: MeOH, Chloroform, EtOAc, THF
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