Sn(IV) Mesoporphyrin IX dichloride 8,13-Bis(ethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid tin(IV) dichloride CAS: 106344-20-1 MDL: MFCD03425982
Field of Interest: HO-1 Inhibitor and Heme Oxygenase Activity
Background: Sn(IV) Mesoporphyrin IX an inhibitor of Heme oxygenase 1 and found active against  intracerebral trauma.1, 2 Heme oxygenase and catabolism forms molecular linkage to neuroendocrine function modified by Sn(IV) mesoporphyrin IX, while modifying heme-iron levels in the intestine.3,4
Molecular weight: 754.29 g/mol
Molecular Formula: C34H36Cl2N4O4Sn
CAS Number: Â 106344-20-1
Storage: Store at room temperature, protect from light
Synonyms: Stannsoporfin, tin mesoporphyrin, Tin Mesoporphyrin IX (chloride), Tin(IV) mesoporphyrin IX dichloride
 References:
1.)Â Â Meffert, Mollie K.; Haley, Jane E.; Schuman, Erin M.; Schulman, Howard; Madison, Daniel V. Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins, Neuron (1994), 13(5), 1225-33 Alderton, Wendy K.; Cooper, Chris E.; Knowles, Richard G., Nitric oxide synthases: structure, function and inhibition, Biochemical Journal (2001), 357(3), 593-615.
2.) Wagner, Kenneth R.; Hua, Ya; De Courten-Myers, Gabrielle M.; Broderick, Joseph P.; Nishimura, Robert N.; Lu, Shi-Yi; Dwyer, Barney E., Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies Cellular and Molecular Biology (Paris) (2000), 46(3), 597-608.
3.)Â Mancuso, Cesare; Kostoglou-Athanassiou, Ifigenia; Forsling, Mary L.; Grossman, Ashley B.; Preziosi, Paolo; Navarra, Pierluigi; Minotti, Giorgio, Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function, Molecular Brain Research (1997), 50(1,2), 267-276.
4.)Â Boni, Roland E.; Boni, Rahel A. Huch; Galbraith, Richard A.; Drummond, George S.; Kappas, Attallah., Tin mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine, Pharmacology (1993), 47(5), 318-29.
