Pyropheophorbide-a methyl ester CAS: 6453-67-4 MDL: MFCD00057989
Molecular weight:Â 548.675 Â g/molÂ
Molecular Formula:Â C34H36N4O3
CAS Number:Â 6453-67-4
Storage: Store at room temperature, protect from light
Synonyms: 6453-67-4, Methyl-3-[(3S,4S)-1
Fields of Interest: Photosensitizer, photodynamic therapy, natural porphyrins and derivatives, non-linear optical imaging
Background:Â Pyropheophorbide-a methyl ester is a natural porphyrin specialty chemical manufactured by Frontier Specialty Chemicals. Pyropheophorbide-a methyl ester has been investigated as a photosensitizer for photodynamic therapy.1The photophysical properties of Pyropheophorbide-a methyl ester have been reported. 2,3Â Modification of Pyropheophorbide-a methyl ester produced compounds useful for non-linear optical imaging.4
 References:
1.) Sun, et al. Photodynamic Therapy with Pyropheophorbide-a Methyl Ester in Human Lung Carcinoma Cancer Cell: Efficacy, Localization and Apoptosis. Photochemistry and Photobiology. Volume 75, Issue 6, June 2002, Pages 644-651. https://doi.org/10.1562/0031-8655(2002)0750644PTWPAM2.0.CO2
2.) Al-Omari, et al. Photodynamic activity of pyropheophorbide methyl ester and pyropheophorbide a in dimethylformamide solution. General Physiology and Biophysics Vol.28, No.1, p.70-77, 2009. 10.4149/gpb_2009_01_70
3.) Delanaye, et al. Physical and chemical properties of pyropheophorbide-a methyl ester in ethanol, phosphate buffer and aqueous dispersion of small unilamellar dimyristoyl-L-α-phosphatidylcholine vesicles. Photochemical & Photobiological Sciences volume 5, pages 317–325 (2006). https://doi.org/10.1039/b513219c
4.) Khadria, et al. Push–pull pyropheophorbides for nonlinear optical imaging. Org. Biomol. Chem., 2017,15, 947-956. https://doi.org/10.1039/C6OB02319C
