Pyropheophorbide-a CAS: 24533-72-0 MDL: MFCD03427571
Product Name: Â Pyropheophorbide a
Catalog Number: PPa
Size:Â 50 mg, 100 mg, 250 mg, 500 mg and larger sizes available, Bulk pricing available
Molecular Formula: C33H34N4O3
MW:Â 534.648 g/molÂ
CAS: 24533-72-0
Storage: Store at room temperature, protect from light
Purity: 95%
Synonyms: 24533-72-0, 3-[(3S,4S)-14-Ethyl
Background: Pyropheophorbide-a is a natural chlorin specialty chemical manufactured by Frontier Specialty Chemicals. Pyropheophorbide-a is commonly used for the synthesis of photosensitizers for photodynamic therapy.1,2 A recent review was published on the bio activities of pyropheophorbide-a.3 The photophysical properties of pyropheophorbide-a have been reported.4 Pyropheophorbide a was found to be an effective visible light photosensitizer for  initiating free-radical photo polymerization.5 Peptide-Pyropheophorbide-a conjugates with tumor specific peptide ligands had been reported.6
References:
1.) Xodo, et al. The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy. Current Medicinal Chemistry, Volume 19, Number 6, 2012, pp. 799-807(9)
2.) Saenz, et al. Structural and Epimeric Isomers of HPPH [3-Devinyl 3-{1-(1-hexyloxy) ethyl}pyropheophorbide-a]: Effects on Uptake and Photodynamic Therapy of Cancer. ACS Chem. Biol. 2017, 12, 4, 933–946. https://doi.org/10.1021/acschembio.7b00023
3.) Saide, et al. Pheophorbide a: State of the Art. Mar. Drugs 2020, 18(5), 257; https://doi.org/10.3390/md18050257
4.) Myrzakhmetov, et. al. Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a, and Photofrin® in Different Conditions. Pharmaceuticals 2021, 14(2), 138; https://doi.org/10.3390/ph14020138
5.) Breloy, et al. Bio-based porphyrins pyropheophorbide a and its Zn-complex as visible-light photosensitizers for free-radical photopolymerization. Polym. Chem., 2022,13, 1658-1671. https://doi.org/10.1039/D1PY01714D
6.) Li, et al. cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy. Mol. Pharmaceutics 2018, 15, 4, 1505–1514. https://doi.org/10.1021/acs.molpharmaceut.7b01064
