Pt(II) Coproporphyrin I CAS: 90540-79-7 MDL: MFCD32662381
Molecular weight:Â 847.77 g/mol
Molecular Formula: C36H36N4O8Pt
CAS Number:Â 90540-79-7
Storage: Store at room temperature, protect from light
Synonyms:Â Pt(II) Coproporphyrin I, 90540-79-7, MFCD32662381, PtCp
Field of Interest:Â Phosphorescent Oxygen Sensors, Natural Porphyrin Derivatives, phosphorescent metalloporphyrin labeling reagents
Background: Pt(II) Coproporphyrin I is a naturally derived porphyrin specialty chemical manufactured by Frontier Specialty Chemicals. Conjugation of Pt(II) Coproporphyrin I with oligoarginine peptides produced a conjugate useful for sensing intracellular O2.1 Pt(II) Coproporphyrin I was used to synthesize phosphorescent metalloporphyrin labeling reagents having an isothiocyanato reactive group.2 Pt(II) Coproporphyrin I conjugates where used as a homogeneous assay for cellular proteases.3 Pt(II) Coproporphyrin I derivatives are used as labels in time-resolved luminescence microscopy.4
References:Â
1.) Dmitriev. et al. Cell-Penetrating Conjugates of Coproporphyrins with Oligoarginine Peptides: Rational Design and Application for Sensing Intracellular O2. Bioconjugate Chem. 2011, 22, 12, 2507–2518. https://doi.org/10.1021/bc200324q
2.) Soini, et al. Preparation of monofunctional and phosphorescent palladium(II) and platinum(II) coproporphyrin labeling reagents. Journal of Porphyrins and Phthalocyanines. Vol. 05, No. 10, pp. 735-741 (2001).
3.) O’Riordan, et al. Homogeneous assays for cellular proteases employing the platinum(II)–coproporphyrin label and time-resolved phosphorescence. Analytical Biochemistry. Volume 342, Issue 1, 1 July 2005, Pages 111-119. https://doi.org/10.1016/j.ab.2005.04.016
4.) Soini, et al. Phosphorescent metalloporphyrins as labels in time-resolved luminescence microscopy: Effect of mounting on emission intensity. Microscopy Research & Technique. Volume 58, Issue 2 Special Issue: The Innervation of Bone 15 July 2002 Pages 125-131. https://doi.org/10.1002/jemt.10129
5.) Papkovsky, D.B., O’Riordan, T.C. Emerging Applications of Phosphorescent Metalloporphyrins. J Fluoresc 15, 569–584 (2005). https://doi.org/10.1007/s10895-005-2830-x
