Protoporphyrin IX disodium salt

Field of Interest: Natural Products Synthesis, Heme Containing Proteins, Hemoglobin, Myoglobin, Cytochrome C pathology, Complexes, Chlorophyll Biosynthesis

 Background: Protoporphyrin IX disodium salt is a porphyrin based natural product that is a starting material for the biosynthesis of heme and chlorophyll. ^1,2   More recently protoporphyrin IX and its congeners have been found active as ligands that promote protein stability and crystallization and activity against telomerases and mammalian cells.^3,4

 References:

1.) Winslow S. Caughey, James A. Ibers, Crystal and Molecular Structure of the Free Base Porphyrin, Protoporphyrin IX Dimethyl Ester, J. Am. Chem. Soc. 99: 1977, 6639–6645.

2.)  Battersby; C. J. R. Fookes; G. W. J. Matcham; E. McDonald, Biosynthesis of the pigments of life: formation of the macrocycle, Nature. 285: 1980, 17–21.

3.) Vedadi, Masoud; Niesen, Frank H.; Allali-Hassani, Abdellah; Fedorov, Oleg Y.; Finerty, Patrick J., Jr.; Wasney, Gregory A.; Yeung, Ron; Arrowsmith, Cheryl; Ball, Linda J.; Berglund, Helena; et al, Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination, Proceedings of the National Academy of Sciences of the United States of America (2006), 103(43), 15835-15840. 

4.) Shi, Dong-Fang; Wheelhouse, Richard T.; Sun, Daekyu; Hurley, Laurence H., Quadruplex-​Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure-​Activity Relationship for the Inhibition of Telomerase, Journal of Medicinal Chemistry (2001), 44(26), 4509-4523.

Protoporphyrin IX disodium salt CAS: 50865-01-5 MDL: MFCD00151108

SDS

Alternative Names

21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, sodium salt (1:2);  3,3′-(3,7,12,17-Tétraméthyl-8,13-divinyl-2,18-porphyrinediyl)dipropanoate de disodium;  7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic Acid Disodium Salt;  Dinatrium-3,3′-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl)dipropanoate;  Disodium 3,3′-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl)dipropanoate;  Disodium 3,3′-(3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-diyl)dipropanoate;  21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, disodium salt;  3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid disodium salt;  Depocolin-S;  Disodium 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7-dipropionate;  disodium 3,3′-(7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-diyl)dipropanoate;  disodium 3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionate;  Disodium protoporphyrin IX;  Ooporphyrin disodium salt;  Palepron;  Protoporphyrin disodium; ;  Protoporphyrin Disodium Salt;  Protoporphyrin IX disodium salt;  PROTOPORPHYRINDISODIUMSALT;  Zinc ionophore II

Sizes Available:        250 mg, 1 g, 5g, and larger sizes available

Molecular Formula: C₃₇H₄₄N₆O₁₀S₂ –₂Na

MW:  606.2

CAS Number:  50865-01-5

Storage:               Store at room temperature, protect from light

Synonyms:          Palepron; Protoporphyrin Disodium; Protoporphyrin IX Disodium Salt,