Pheophorbide a (mixture of diastereomers)

Pheophorbide a (mixture of diastereomers) CAS: 15664-29-6 MDL: MFCD00210345

Background: Pheophorbide a is active as a photosensitizer in solar cell applications and is a substrate for mammalian cell transport proteins.^{1, 2} It also is a catabolite of photosynthetic processes and a breakdown product of chlorophyll during senescence caused by oxygenases. ^3,4

Molecular weight: 592.7 g/mol

Molecular Formula: C₃₅H₃₆N₄O₅          

CAS Number:  15664-29-6

Storage: Store at room temperature, protect from light

Synonyms: Pheophorbide a,  15664-29-6,  Phaeophorbid a,  Phaeophorbid-a,   Phaeophorbide A,  UNII-IA2WNI2HO2,  EINECS 239-738-5,  IA2WNI2HO2,  CHEBI:38257, CHEMBL510103,  CHEMBL2006244

References:

1.) Kay, Andreas; Graetzel, Michael, Artificial photosynthesis.   Photosensitization of titania solar cells with chlorophyll derivatives and related natural porphyrins, Journal of Physical Chemistry (1993), 97(23), 6272-7.

2.)  Robey, Robert W.; Steadman, Kenneth; Polgar, Orsolya; Morisaki, Kuniaki; Blayney, Margaret; Mistry, Prakash; Bates, Susan E., 9. Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition, Cancer Research (2004), 64(4), 1242-1246. DOI:10.1158/0008-5472.CAN-03-3298.

3.)  Schelbert, Silvia; Aubry, Sylvain; Burla, Bo; Agne, Birgit; Kessler, Felix; Krupinska, Karin; Hortensteiner, Stefan, Pheophytin pheophorbide hydrolase (pheophytinase) is involved in chlorophyll breakdown during leaf senescence in Arabidopsis, Plant Cell (2009), 21(3), 767-785. DOI:10.1105/tpc.108.064089.

4.)  Pruzinska, Adriana; Tanner, Gaby; Anders, Iwona; Roca, Maria; Hoertensteiner, Stefan, Chlorophyll breakdown: pheophorbinde a oxygenase is a Rieske-type iron-sulfur protein, encoded by the accelerated cell death 1 gene, Proceedings of the National Academy of Sciences of the United States of America (2003), 100(25), 15259-15264. DOI:10.1073/pnas.2036571100

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