Name: N1,N14-Dimethyl-3,6,9,12-tetraoxatetradecane-1,14-diamine (97%)
Molecular Formula: C10H28N2O4
CAS#: 72236-27-2
SMILES: CNCCOCCOCCOCCOCCNC
MDL#: none found
Catalog#: AMTGC804-DI21
Molecular weight: 264.36 g/mol
Other names:
- MeNH-PEG5-NHMe
- 1,16-diazo-1,16-dimethyl-4,7,10,13-tetraoxahexadecane
Fields of Interest: PEGylation, crosslinking, bioconjugation, materials science
Background & Applications:
Background
N¹,N¹⁴-Dimethyl-3,6,9,12-tetraoxatetradecane-1,14-diamine (CAS 72236-27-2) is a symmetrical diamino-functionalized PEG derivative based on a PEG4 backbone, featuring secondary amine groups at both termini. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments while offering defined linker length for spatial control. The secondary amines enable controlled reactivity toward activated carboxylic acids, NHS esters, isocyanates, and related electrophiles, making this compound well suited for stepwise or selective conjugation strategies. This bifunctional PEG linker is a valuable building block within a versatile portfolio of functionalized PEGs designed for controlled molecular assembly and crosslinking.
Applications
N¹,N¹⁴-Dimethyl-3,6,9,12-tetraoxatetradecane-1,14-diamine is commonly used in crosslinking, bioconjugation, and materials science applications where dual secondary amine reactivity and defined PEG spacing are required. Typical uses include preparation of PEG-based networks, construction of multifunctional intermediates, and surface or polymer modification. As part of a comprehensive functionalized PEG product line, this dimethylated PEG4 diamine supports modular design strategies in pharmaceutical research, biomaterials development, and specialty chemical synthesis where controlled amine reactivity is advantageous.
Appearance: yellow liquid
Purity: 97%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH, EtOAc
Literature:
- MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG - WO2020/152067, 2020, A1
