Name: N-Methyl-3,6,9,12,15-pentaoxahexadecan-1-amine (98%)
Molecular Formula: C12H27NO5
CAS#: 936499-79-5
SMILES: CNCCOCCOCCOCCOCCOC
MDL#: MFCD35221304
Catalog#: AMTGC675-MP20
Molecular weight: 265.35 g/mol
Other names:
- mPEG5-NHMe
- 1-methoxy-14-methylamino-3,6,9,12-tetraoxa-tetradecane
Fields of Interest: PEGylation, bioconjugation, drug delivery, materials science
Background & Applications:
Background
N-Methyl-3,6,9,12,15-pentaoxahexadecan-1-amine (CAS 936499-79-5) is a monofunctional amine-terminated PEG derivative based on a PEG5 backbone, featuring a terminal secondary amine. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments while offering extended linker length for spatial separation and conformational freedom. The secondary amine functionality enables controlled reactivity toward activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable molecular modification.
Applications
N-Methyl-3,6,9,12,15-pentaoxahexadecan-1-amine is commonly used in bioconjugation, drug delivery, and materials science applications where longer PEG spacing and monofunctional secondary amine reactivity are required. Typical uses include PEGylation of small molecules and polymers to enhance solubility and stability, surface and nanoparticle modification, and preparation of functional intermediates for pharmaceutical and biomaterials research. As part of a robust functionalized PEG product line, this PEG5 secondary amine supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Pale yellow liquid
Purity: 98%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform, MeOH
Literature: Dalton Transactions, 2007, # 13, p. 1309 – 1315.
