meso-Tetra (N-methyl-2-pyridyl) porphine tetrachloride

Product Number: T40846; CAS Number: 129051-18-9

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meso-Tetra (N-methyl-2-pyridyl) porphine tetrachloride CAS: 129051-18-9 MDL: MFCD06411460

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Molecular weight: 820.638 g/mol

Molecular Formula: C44H38Cl4N8

CAS Number: 129051-18-9

Storage: Store at room temperature, protect from light.

Synonyms: 2,2′,2”,2”’-(5,10,15,20-Porphyrintetrayl)tetrakis(1-methylpyridinium) tetrachloride, 2,2′,2”,2”’-(5,10,15,20-Porphyrintetrayl)tetrakis(1-methylpyridinium)tetrachlorid, 2,2′,2”,2”’-porphyrin-5,10,15,20-tetrayltetrakis(1-methylpyridinium) tetrachloride, Pyridinium, 2,2′,2′‘,2”’-(21H,22H-porphine-5,10,15,20-tetrayl)tetrakis[1-methyl-, chloride (1:4), Tétrachlorure de 2,2′,2”,2”’-(5,10,15,20-porphyrinetétrayl)tétrakis(1-méthylpyridinium), 129051-18-9, 1-Methyl-2-(porphyrin-5,10,15,20-yl)-tetrapyridinium chloride, meso-Tetra (N-methyl-2-pyridyl) porphine tetrachloride, MFCD06411460

Fields of Interest: Water Soluble Porphyrins, G-Quadruplex

Background: meso-Tetra (N-methyl-2-pyridyl) porphine tetrachloride is a synthetic porphyrin specialty chemical manufactured by Frontier Specialty Chemicals. meso-Tetra (N-methyl-2-pyridyl) porphine tetrachloride is used as a control in G-quadruplex studies since it does not bind to G-quadruplexes.1-6

References:

1.) David, et al. G-quadruplexes as novel cis-elements controlling transcription during embryonic development. Nucleic Acids Research, Volume 44, Issue 9, 19 May 2016, Pages 4163–4173, https://doi.org/10.1093/nar/gkw011

2.) Alonso, et al. A rapid and sensitive high-throughput screening method to identify compounds targeting protein–nucleic acids interactions. Nucleic Acids Research, Volume 43, Issue 8, 30 April 2015, Page e52, https://doi.org/10.1093/nar/gkv069

3.) Ravichandran, et al. Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus. PLOS Pathogens, Published: September 28, 2018 https://doi.org/10.1371/journal.ppat.1007334

4.) Wu, et al. DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation. PNAS. September 23, 2019, 116 (41) 20453-20461. https://doi.org/10.1073/pnas.1909047116

5.) Faudale, et al. Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation. Chem. Commun., 2012,48, 874-876. https://doi.org/10.1039/C1CC15850C

6.) Shi, et al. Quadruplex-Interactive Agents as Telomerase Inhibitors:  Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase. J. Med. Chem. 2001, 44, 26, 4509–4523. https://doi.org/10.1021/jm010246u

Categories

Porphyrins
Scaffold/Subcategory

Synthetic Porphyrins
CAS #

[129051-18-9]
Purity %

>95%
Smiles

[Cl-].[Cl-].[Cl-].[Cl-].C[N+]1=C(C=CC=C1)C1=C2NC(C=C/2)=C(/C2=N/C(/C=C2)=C(C2=CC=C(N2)/C(C2=[N+](C)C=CC=C2)=C2/C=CC1=N/2)C1=[N+](C)C=CC=C1)C1=[N+](C)C=CC=C1
Molecular Weight

820.638
Molecular Formula

C44H38Cl4N8
Functional Groups

Nitrogen Heterocycle, Quaternary Ammonium
Porphyrin Family

A4 Porphyrins, Free Base Porphyrins, Tetra-Phenyl Porphine Derivatives, Water Soluble Porphyrins
Porphyrin Substitution

Meso-Substituted Porphyrins, Pyridyl Substituted Porphyrins

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