Fe57 (III) Protoporphyrin IX chloride

Fe57 (III) Protoporphyrin IX chloride CAS: MDL:

SDS

Molecular weight: g/mol

Molecular Formula: 

CAS Number: 

Storage: Store at room temperature, protect from light.

Synonyms: 57Fe Heme

Fields of Interest: Isotopically labeled Heme, Biosynthetic Studies, Mössbauer Spectroscopy

Background: Fe57 (III) Protoporphyrin IX chloride is a natural porphyrin derivative specialty chemical manufactured by Frontier Specialty Chemicals. Fe57 (III) Protoporphyrin IX chloride has been used to study heme proteins by Mössbauer Spectroscopy.^1-3 Protoporphyrin IX chloride was used to visualize the location of heme in biological studies.^4-6

References:

1.) Bearden, et al. Mössbauer spectroscopy of heme and hemin compounds. PNAS, June 1, 1965, 53 (6) 1246-1253. https://doi.org/10.1073/pnas.53.6.1246

2.) Weissbluth, M. (1967). The physics of hemoglobin. In: Jørgensen, C.K., Neilands, J.B., Nyholm, R.S., Reinen, D., Williams, R.J.P. (eds) Structure and Bonding. Structure and Bonding, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0118872

3.) Johnson, C.E. (1975). Mössbauer spectroscopy in biology. In: Gonser, U. (eds) Mössbauer Spectroscopy. Topics in Applied Physics, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3540071202_16

4.) Joubert, L., Dagieu, JB., Fernandez, A. et al. Visualization of the role of host heme on the virulence of the heme auxotroph Streptococcus agalactiae. Sci Rep 7, 40435 (2017). https://doi.org/10.1038/srep40435

5.) Zeng, et al. Direct Probe of Iron Vibrations Elucidates NO Activation of Heme Proteins J. Am. Chem. Soc. 2005, 127, 32, 11200–11201. https://doi.org/10.1021/ja051052x

6.) Kihara, Visualization of ⁵⁷Fe-Labeled Heme Isotopic Fine Structure and Localization of Regions of Erythroblast Maturation in Mouse Spleen by MALDI FTICR-MS Imaging. J. Am. Soc. Mass Spectrom. 2017, 28, 11, 2469–2475. https://doi.org/10.1007/s13361-017-1768-y