Deuteroporphyrin IX dihydrochloride 3,7,12,17-Tetramethyl-21H,23H-porphine-2,18-dipropionic acid dihydrochloride CAS: 68929-05-5 MDL: MFCD00058926
Molecular weight: 581.490
Molecular Formula: C30H30Cl2N4O
CAS Number: 68929-05-5
Storage: Store at room temperature, protect from light.
Synonyms: 3,3′-(3,7,12,17-Tetramethyl-2,
Fields of Interest: Photosensitizers, natural porphyrins
Background: Deuteroporphyrin IX dihydrochloride is a naturally derived porphyrin specialty chemical manufactured by Frontier Specialty Chemicals. Oxidation of deuteroporphyrin by horse radish peroxidase produces two novel chlorin derivatives.1 Deuteroporphyrin IX was found to photodynamically inactivate Staphylococcus aureus.2 Deuteroporphyrin IX is an analogue of protoporphyrin IX that is much more soluble and stable and can be converted to deuteroheme (an analogue of heme) by the ferrochelatase enzyme but cannot be incorporated into hemoproteins.3
References:
1.) Pont, Formation of Chlorins by Oxidation of Deuteroporphyrin with Horseradish Peroxidase. Tetrahedron Letters Volume 38, Issue 36, 8 September 1997, Pages 6383-6384. https://doi.org/10.1016/S0040-4039(97)01446-9
2.) Nitzan, et al. The mechanism of photodynamic inactivation of Staphylococcus aureus by deuteroporphyrin. Current Microbiology volume 19, pages 265–269 (1989).
3.) Bouchez, et al. “Labile” heme critically regulates mitochondrial biogenesis through the transcriptional co-activator Hap4p in Saccharomyces cerevisiae. JBC VOLUME 295, ISSUE 15, P5095-5109, APRIL 2020. https://doi.org/10.1074/jbc.RA120.012739