Coproporphyrin III dihydrochloride

Coproporphyrin III dihydrochloride 3,8,13,17-Tetramethyl-21H,23H-porphine-2,7,12,18-tetrapropionic acid dihydrochloride CAS: 14643-66-4 MDL: MFCD00058927

Field of Interest: Heme Metabolism, Rare Diseases, Porphyrias, Mitochondria

 Background: Coproporphyrin a porphyrin based metabolic product of heme catabolism implicated in porphyria diseases and  in heavy metal exposure^1,2   This specialty chemical has photosensitizing properties and has shown to form ordered micelles and aggregates under aqueous conditions.^3,4 Copropoprhyrin I and III can be analyzed by HPLC and LCMS.^5,6

Molecular weight: 727.63 g/mol

Molecular Formula: C₃₆H₃₈N₄O₈ • 2HCl       

 CAS Number:  14643-66-4

Storage: Store at room temperature, protect from light

Synonyms:  Coproporphyrin III,  14643-66-4,  Zincphyrin,  21H,23H-Porphine-2,7,12,18-tetrapropanoic acid, 3,8,13,17-tetramethyl-, Zinc coproporphyrin III,  3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrapropanoic acid,  Koproporphyrin,  Koproporphyrin III

References: 

 1.)  B Cribier^, D Rey, G Uhl, C Le Coz, C Hirth, E Libbrecht, D Vetter, J M Lang, F Stoll-Keller, Abnormal urinary coproporphyrin levels in patients infected by hepatitis C virus with or without human immunodeficiency virus. A study of 177 patients, Arch Dermatol, 1996 Dec;132(12):1448-52. 

2.)  Mahaffey, Kathryn R.; Capar, Stephen G.; Gladen, Beth C.; Fowler, Bruce A., Concurrent exposure to lead, cadmium, and arsenic. Effects on toxicity and tissue metal concentrations in the rat, Journal of Laboratory and Clinical Medicine (1981), 98(4), 463-81.

3.)  Finlay, Jarod C.; Conover, David L.; Hull, Edward L.; Foster, Thomas H., Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo, Photochemistry and Photobiology (2001), 73(1), 54-63.

4.)  Brown, Stanley B.; Shillcock, Margaret; Jones, Peter, Equilibrium and kinetic studies of the aggregation of porphyrins in aqueous solution, Biochemical Journal (1976), 153(2), 279-85. Language: English, Database: CAPLUS

5.) High-performance liquid chromatography of uroporphyrin and coproporphyrin isomers. Lim ,et al. Methods in Enzymology Volume 123, 1986, Pages 383-389. https://doi.org/10.1016/S0076-6879(86)23046-3

6.) A fully automated and validated human plasma LC–MS/MS assay for endogenous OATP biomarkers coproporphyrin-I and coproporphyrin-III. King-Ahmad, et al. BIOANALYSIS VOL. 10, NO. 9. https://doi.org/10.4155/bio-2017-0270

SDS