Chlorin e4

Chlorin e4 CAS: 550-52-7 MDL: MFCD10566749

SDS

Molecular weight: 552.7 g/mol

Molecular Formula: C₃₃H₃₆N₄O₄                              

CAS Number:  550-52-7

Storage: Store at –20 °C, protect from light.

Synonyms: SCHEMBL14039063, 21H,23H-PORPHINE-7-PROPANOIC ACID, 3-CARBOXY-13-ETHENYL-18-ETHYL-7,8-DIHYDRO-2,5,8,12,17-PENTAMETHYL-, (7S,8S)-, J2.069.722I, (7S,8S)-3-Carboxy-13-ethenyl-18-ethyl-7,8-dihydro-2,5,8,12,17-pentamethyl-21H,23H-porphyrin-7-propanoic acid.

Alternative Chemical Names

(17S,18S)-18-(2-Carboxyethyl)-7-ethyl-3,8,13,17,20-pentamethyl-12-vinyl-17,18-dihydro-2-porphyrincarbonsäure, (17S,18S)-18-(2-Carboxyethyl)-7-ethyl-3,8,13,17,20-pentamethyl-12-vinyl-17,18-dihydro-2-porphyrincarboxylic acid, 21H,23H-Porphine-7-propanoic acid, 3-carboxy-13-ethenyl-18-ethyl-7,8-dihydro-2,5,8,12,17-pentamethyl-, (7S,8S)-, Acide (17S,18S)-18-(2-carboxyéthyl)-7-éthyl-3,8,13,17,20-pentaméthyl-12-vinyl-17,18-dihydro-2-porphyrinecarboxylique, (7S,8S)-3-carboxy-13-ethenyl-18-ethyl-7,8-dihydro-2,5,8,12,17-pentamethyl-21H,23H-Porphine-7-propanoic acid, 21H,23H-Porphine-7-propanoic acid,3-carboxy-13-ethenyl-18-ethyl-7,8-dihydro-2,5,8,12,17-pentamethyl-,(7s,8s)-

Field of Interest: Natural Products Synthesis, Inflammation Activity, Solar Cells

Background: Chlorin e4 is a porphyrin based natural product and fine chemical that possesses photophysical properties while cytoprotective in mammalian cells. ^1,2 This compound is found in chlorophyllin extracts, and may add to its chemoprevention properties, and have high membrane affinity compared to porphyrins.^{3, 4}

References: 

1.) Wang, Xiao-Feng; Kitao, Osamu, Natural chlorophyll-related porphyrins and chlorins for dye-sensitized solar cells, Molecules (2012), 17, 4484-4497.

2.) Fahey Jed W; Stephenson Katherine K; Dinkova-Kostova Albena T; Egner Patricia A; Kensler Thomas W; Talalay Paul, Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes , Carcinogenesis (2005), 26(7), 1247-55.

3.) Egner, Patricia A.; Stansbury, Kevin H.; Snyder, Edward P.; Rogers, Mark E.; Hintz, Paul A.; Kensler, Thomas W., Identification and Characterization of Chlorin e4 Ethyl Ester in Sera of Individuals Participating in the Chlorophyllin Chemoprevention Trial, Chemical Research in Toxicology (2000), 13(9), 900-906.

4.)  Vermathen, Martina; Marzorati, Mattia; Bigler, Peter, Self-Assembling Properties of Porphyrinic Photosensitizers and Their Effect on Membrane Interactions Probed by NMR Spectroscopy,  Journal of Physical Chemistry B (2013), 117(23), 6990-7001.