Biliverdin hydrochloride

Biliverdin hydrochloride CAS: 55482-27-4 MDL: MFCD08669554

SDS

Molecular weight: 619.12 g/mol 

Molecular Formula: C₃₃H₃₅ClN₄O₆

CAS Number:  55482-27-4

Storage: Store at room temperature, protect from light

Synonyms: biliverdin, biliverdine, Biliverdine Ix Alpha, Biliverdin IX alpha, uteroverdine, UNII-O9MIA842K9, dehydrobilirubin, CHEMBL455477, SCHEMBL20503445

Field of Interest: Natural Products, Heme Oxygenase Catabolism, Carbon Monoxide, Anti-oxidant, Cell Protectant

Background: Biliverdin is a linear pyrrole based green bile natural product and a product of heme catabolism and the heme oxygenase (HO-1) system, and the product along with carbon monoxide gases of physiological relevance.^1,2   Biliverdin is reduced to form bilirubin, a potent anti-oxidant and cell protectant.^3,4

References: 

1.)  Maines, Mahin D., The heme oxygenase system: a regulator of second messenger gases, Annual Review of Pharmacology and Toxicology (1997), 37, 517-554

2.)  Otterbein, Leo E.; Soares, Miguel P.; Yamashita, Kenichiro; Bach, Fritz H., Heme oxygenase-1: unleashing the protective properties of heme, Trends in Immunology (2003), 24(8), 449-455.

3.)  Stocker R; Yamamoto Y; McDonagh A F; Glazer A N; Ames B N, Bilirubin is an antioxidant of possible physiological importance, Science (New York, N.Y.) (1987), 235(4792), 1043-6.

4.)  Baranano, David E.; Rao, Mahil; Ferris, Christopher D.; Snyder, Solomon H, Biliverdin reductase: a major physiologic cytoprotectant, Proceedings of the National Academy of Sciences of the United States of America (2002), 99(25), 16093-16098.