5,15-diphenylporphine

5,15-diphenylporphine CAS: 22112-89-6 MDL: MFCD08276335

Molecular weight: 462.544 g/mol

Molecular Formula: C₃₂H₂₂N₄

CAS Number: 22112-89-6

Storage: Store at room temperature, protect from light.

Synonyms: 21H,23H-Porphine, 5,15-diphenyl-, 22112-89-6, 5, 15-DPP, 5,15-Diphenyl-21H,23H-porphine, 5,15-diphenylporphine, 5,15-diphenyl-Porphine,5,15-Diphenylporphyrin, 5,15-Diphenylporphyrin, 5,15-Diphénylporphyrine, MFCD08276335, 5,15-diphenyl porphyrin, 5,15-diphenyl-21H,23H-porphyrin, 5,15-diphenyl-21H,23H-porphine, STAT3 Inhibitor VIII. 

Fields of Interest: Synthetic Porphyrins, 5,15-Disubstituted Porphyrins, STAT3 Inhibitors

Background: 5,15-diphenylporphine is a synthetic porphyrin specialty chemical manufactured by Frontier Specialty Chemicals. 5,15-diphenylporphyrin (5,15-DPP) is reported to be a selective STAT3–SH2 antagonist.¹ 5,15-diphenylporphine can be monofunctionalized at the meso position to give unsymmetrical porphyrins.^2,3

References:

1.) Uehara, et al. Novel high-throughput screening system for identifying STAT3–SH2 antagonists. Biochemical and Biophysical Research Communications. Volume 380, Issue 3, 13 March 2009, Pages 627-631.

2.) Boyle, et al. Iodination and Heck alkynylation of 5,15-diphenylporphyrin. A convenient entry to asymmetrically meso-substituted porphyrins. J. Chem. Soc., Chem. Commun., 1995, 527-528.  https://doi.org/10.1039/C39950000527

3.) Sakthi, et al. Regioselective halogenation and palladium-catalysed couplings on 5,15-diphenylporphyrin. Journal of Porphyrins and Phthalocyanines. Vol. 04, No. 03, pp. 228-232 (2000).