50 mg (PPa)

Pyropheophorbide-a CAS: 24533-72-0 MDL: MFCD03427571

Molecular weight: 534.7  g/mol

Molecular Formula: C₃₃H₃₄N₄O₃

CAS Number:  24533-72-0

Storage:               Store at–20 °C, under dry conditions.

Synonyms:   Pyropheophorbide a, Pyropheophorbide-a, PYROPHEOPHORBIDE, 24533-72-0, CHEBI:48398, 3S-trans)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid, 3-[(3S,4S)-14-ethyl-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbin-3-yl]propanoic acid, pyrophaeophorbide, SCHEMBL378992, CHEMBL520220, CHEMBL1807359

Field of Interest: Natural Porphyrin, Catalyst, Radical Scavenger

 Background: Pyropheophorbide a is a natural product and fine chemical that has photodynamic activities,  while derivatives are potent photosensitizers used in medicine.  ^1-4

References:   1)  Roy, Indrajit; Ohulchanskyy, Tymish Y.; Pudavar, Haridas E.; Bergey, Earl J.; Oseroff, Allan R.; Morgan, Janet; Dougherty, Thomas J.; Prasad, Paras N. Ceramic-​based nanoparticles entrapping water-​insoluble photosensitizing anticancer drugs: a novel drug-​carrier system for photodynamic therapy, Journal of the American Chemical Society (2003), 125(26), 7860-7865. Language: English, Database: CAPLUS, DOI:10.1021/ja0343095  2)  He, Chunbai; Duan, Xiaopin; Guo, Nining; Chan, Christina; Poon, Christopher; Weichselbaum, Ralph R.; Lin, Wenbin, Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy, Nature Communications (2016), 7, 12499. DOI:10.1038/ncomms12499  3)  Bellnier, David A.; Greco, William R.; Loewen, Gregory M.; Nava, Hector; Oseroff, Allan R.; Pandey, Ravindra K.; Tsuchida, Takaaki; Dougherty, Thomas J., Population Pharmacokinetics of the Photodynamic Therapy Agent 2-[1-Hexyloxyethyl]-2-devinyl Pyropheophorbide-a in Cancer Patients, Cancer Research (2003), 63(8), 1806-1813  4)  Snyder, John W.; Greco, William R.; Bellnier, David A.; Vaughan, Lurine; Henderson, Barbara W., Photodynamic Therapy: A Means to Enhanced Drug Delivery to Tumors, Cancer Research (2003), 63(23), 8126-8131.