Name: 3,6,9,12-Tetraoxapentadec-14-yn-1-amine
Molecular Formula: C11H21NO4
CAS#: 1013921-36-2
SMILES: NCCOCCOCCOCCOCC#C
MDL#: MFCD22380736
Catalog#: AMTGC1275-PT24
Molecular weight: 231.29 g/mol
Other names:
- Propargyl-PEG4-Amine
Fields of Interest: PEGylation, bioconjugation, click chemistry, drug delivery, materials science
Background & Applications:
Background
3,6,9,12-Tetraoxapentadec-14-yn-1-amine (CAS 1013921-36-2) is a heterobifunctional alkyne-functionalized PEG linker based on a PEG4 backbone, featuring a terminal alkyne group and a primary amine. The polyethylene glycol spacer provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments, while maintaining defined linker length. The terminal alkyne enables efficient bioorthogonal click chemistry, most commonly copper-catalyzed azide–alkyne cycloaddition (CuAAC), and the primary amine allows straightforward coupling to activated carboxylic acids, NHS esters, and isocyanates. This dual-functional PEG linker is a valuable building block within a versatile portfolio of functionalized PEGs designed for precise and predictable molecular conjugation.
Applications
3,6,9,12-Tetraoxapentadec-14-yn-1-amine is commonly used in bioconjugation, drug delivery, and materials science applications requiring orthogonal reactivity and defined PEG spacing. Typical uses include click-based attachment to azide-functionalized molecules followed by amide bond formation, preparation of multifunctional intermediates, and surface or nanoparticle modification. As part of a comprehensive functionalized PEG product line, this alkyne–amine PEG supports modular design strategies for pharmaceutical research, diagnostics, biomaterials, and advanced materials development.
Appearance: Colorless liquid
Purity: 97%
Storage: 0-3 °C for long term storage
Solubility: DCM, Chloroform
Literature:
- ACS Medicinal Chemistry Letters, 2025, vol. 16, # 2, p. 278 – 284
- Nature Microbiology, 2025, vol. 10, # 4, art. no. 6114, p. 912 – 926
