2,5,8,11,14,17-Hexaoxanonadecan-19-amine (98%)

Name: 2,5,8,11,14,17-Hexaoxanonadecan-19-amine (98%)          

Molecular Formula: C13H29NO6 

CAS#: 184357-46-8 

SMILES: COCCOCCOCCOCCOCCOCCN 

MDL#: MFCD16619273 

Catalog#: AMTGC327-DA17 

Molecular weight:   295.37   g/mol 

Other names: 

• m-PEG6-Amine 
• PEG6 amine 
• Amino-PEG6 
• α-Amino-hexaethylene glycol 

Fields of Interest: PEGylation, bioconjugation, drug delivery, materials science 

Background & Applications:  

Background
2,5,8,11,14,17-Hexaoxanonadecan-19-amine (CAS 184357-46-8) is a monofunctional amine-terminated PEG derivative based on a PEG6 backbone, featuring a terminal primary amine. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments while offering extended linker length for increased spatial separation and conformational freedom. The primary amine functionality enables efficient coupling to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This compound serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for predictable molecular modification. 

Applications
2,5,8,11,14,17-Hexaoxanonadecan-19-amine is commonly used in bioconjugation, drug delivery, and materials science applications where longer PEG spacing and monofunctional amine reactivity are required. Typical uses include PEGylation of small molecules, peptides, and polymers to enhance solubility and stability, surface and nanoparticle functionalization, and preparation of intermediates for pharmaceutical and biomaterials research. As part of a robust functionalized PEG product line, this PEG6 amine supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development. 

Appearance: Colorless liquid 

Purity: 98% 

Storage: 0-3 °C for long term storage 

Solubility: DCM, Chloroform, MeOH

Literature:  

1. ChemMedChem, 2020, vol. 15, # 20, p. 1909 – 1920.  
2. Journal of the American Chemical Society, 2020, vol. 142, # 6, p. 2915 – 2924.