2,5,8,11-Tetraoxatridecan-13-amine (99%)

Name: 2,5,8,11-Tetraoxatridecan-13-amine (99% purity) 

Molecular Formula: C9H21NO4 

CAS#: 85030-56-4 

SMILES: NCCOCCOCCOCCOC 

MDL#: MFCD11041099 

Catalog#: AMTGC297-AT17 

Molecular weight: 207.27 g/mol 

Other names: 

• 3,6,9,12-tetraoxa-tridecylamine 

• 3,6,9,12-tetraoxatridecan-1-amine 

Fields of Interest: PEGylating reagent, Organic Synthesis, Medicinal Chemistry 

Background & Applications:  

Background
2,5,8,11-Tetraoxatridecan-13-amine (CAS 85030-56-4) is a monofunctional amine-terminated PEG derivative featuring a PEG4 backbone with a terminal primary amine. The polyethylene glycol chain provides hydrophilicity, flexibility, and reduced non-specific interactions, making this compound well suited for use in aqueous and biological environments. The primary amine functionality enables efficient conjugation to activated carboxylic acids, NHS esters, isocyanates, and related electrophiles. This molecule serves as a versatile intermediate within a comprehensive portfolio of functionalized PEGs designed for controlled and predictable molecular modification. 

Applications
2,5,8,11-Tetraoxatridecan-13-amine is commonly used in bioconjugation, drug delivery, and materials science applications where monofunctional amine reactivity and defined PEG spacing are required. Typical uses include PEGylation of small molecules, peptides, and polymers to enhance solubility and stability, surface and nanoparticle functionalization, and preparation of intermediates for biomaterials and pharmaceutical research. As part of a robust functionalized PEG product line, this amine-terminated PEG supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development. 

Appearance: Pale yellow liquid 

Purity: 99% 

Storage: 0-3 °C for long term storage 

Solubility: Water, DMSO 

Literature: 

1. ACS Medicinal Chemistry Letters, 2025, vol. 16, # 1, p. 80 – 88 
2. RSC Medicinal Chemistry, 2025, vol. 16, # 9, p. 4194 – 4207