Product Number: C13480; CAS Number: 1184172-46-0

C13480 Technical Data Sheet 




2-Chloro-3-fluoro-4-hydroxypyridine 2-Chloro-3-fluoropyridin-4-ol CAS: 1184172-46-0 MDL: MFCD13189885


Molecular weight: 147.53  g/mol

Molecular Formula: C5H3ClFNO

CAS Number: 1184172-46-0

Storage: Store at 2-8 Co, under dry conditions.

Synonyms: 2-Chloro-3-fluoropyridin-4-ol, 1184172-46-0, 2-CHLORO-3-FLUORO-4-HYDROXYPYRIDINE, 2-chloro-3-fluoro-1H-pyridin-4-one, SCHEMBL4374332, 2-Chloro-3-fluoropyridine-4-ol

Uses: Synthesis reagent, building block, pyridine heterocycle, fluorochemical

2-Chloro-3-fluoro-4-hydroxypyridine, is a synthetic specialty chemical useful in the synthesis of pharmaceuticals and specialty organic chemicals.

Selected References:

1.) Preparation of imidazo[1,2-a]pyridinyl derivatives and their use in the treatment of disease, Peterson, Emily Anne; Evans, Ryan; Gao, Fang; Bolduc, Philippe; Pfaffenbach, Magnus; Xin, Zhili; May-Dracka, Tricia,  PCT Int. Appl. (2020), WO 2020263980 A1 20201230

2.) Preparation of imidazo[1,2-a]pyridinyl derivatives as IRAK4 inhibitors, Hopkins, Brian T.; Pfaffenbach, Magnus; May-Dracka, Tricia; Evans, Ryan; Gao, Fang; Enyedy, Istvan; Xin, Zhili; Bolduc, Philippe; Peterson, Emily AnnePCT Int. Appl. (2020), WO 2020150626 A1 20200723

3.) Preparation of bicyclic heterocycle derivatives having selective BACE1 inhibitory activity, Ueno, Tatsuhiko; Fuchino, Kouki; Fujimoto, Kazuki; Rombouts, Frederik; Van den Bossche, Dries; Surkyn, Michel; De Cleyn, MichelPCT Int. Appl. (2019), WO 2019208509 A1 20191031

4.) Preparation of tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity, Tadano, Genta; Suzuki, Shinji; Kusakabe, Ken-Ichi, PCT Int. Appl. (2019), WO 2019208693 A1 20191031

5.) Novel synthetic approach to fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones, Ma, Yongmin; Hider, Robert C., Journal of Fluorine Chemistry (2015), 173, 29-34. DOI:10.1016/j.jfluchem.2015.02.005

6.) Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values hydroxypyridin-4-one, Chen, Yu-Lin; Barlow, Dave J.; Kong, Xiao-Le; Ma, Yong-Min; Hider, Robert C., Dalton Transactions (2012), 41(21), 6549-6557.  DOI:10.1039/c2dt12396g

7.) Design and Synthesis of Fluorinated Iron Chelators for Metabolic Study and Brain Uptake, Ma, Yongmin; Roy, Sourav; Kong, Xiaole; Chen, Yulin; Liu, Dingyong; Hider, Robert C., Journal of Medicinal Chemistry (2012), 55(5), 2185-2195. DOI:10.1021/jm201475u

8.) Fluorinated pyridin-4-ones as metal chelating agents useful in the treatment of metal ion related diseases and their preparation,Hider, Robert Charles; Ma, Yongmin,PCT Int. Appl. (2009), WO 2009103950 A1 20090827


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