Name: 2-(2-(2-(Methylamino)ethoxy) ethoxy)ethanol (98% purity)
Molecular Formula: C7H17NO3
CAS#: 282551-10-4
SMILES: CNCCOCCOCCO
MDL#: MFCD30182052
Catalog#: AMTGC442-MA18
Molecular weight: 163.21 g/mol
Other names:
- 2-(2-(2-(methylamino)ethoxy)ethoxy)ethan-1-ol
Fields of Interest: PEGylating reagent, Organic Synthesis, Medicinal Chemistry
Background & Applications:
2-(2-(2-(Methylamino)ethoxy)ethoxy)ethanol is a monofunctional amine-functionalized PEG derivative based on a PEG2 backbone, featuring a terminal secondary amine and a hydroxyl group at the opposite end. The polyethylene glycol chain provides hydrophilicity, flexibility, and compatibility with aqueous and biological environments. The secondary amine functionality enables selective coupling to activated electrophiles, while the hydroxyl group offers additional derivatization options or can remain unreactive for controlled, single-point modification. This compound is a useful intermediate within a versatile portfolio of functionalized PEGs designed for predictable and modular molecular functionalization.
Applications
This methylamine-terminated PEG derivative is commonly used in bioconjugation, drug delivery, and materials science applications where controlled amine reactivity and short PEG spacing are desired. Typical uses include PEGylation of small molecules and polymers to improve solubility and stability, preparation of functional intermediates for pharmaceutical and biomaterials research, and surface or nanoparticle modification. As part of a comprehensive functionalized PEG product line, 2-(2-(2-(Methylamino)ethoxy)ethoxy)ethanol supports modular design strategies in specialty chemical synthesis, diagnostics, and advanced materials development.
Appearance: Colorless oil
Purity: 98%
Storage: 0-3 °C for long term storage
Solubility: Water, Polar Organic Solvents
Literature: European Journal of Organic Chemistry, 2017, vol. 2017, # 19, p. 2683 – 2691
